REGULATION OF NUTRIENT-STIMULATED INSULIN SECRETION BY GLP-1

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究旨在测试肠道激素GLP-1对控制健康人和糖尿病患者胰岛素分泌的作用。为了进行这项研究，志愿者将在两次餐后测量胰岛素水平。在其中一项研究中，GLP-1的作用将通过给予GLP-1的阻断剂exendin-β 9-39来确定。通过比较有和没有GLP-1阻断的胰岛素分泌，可以根据两项研究的差异估计GLP-1的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to test the effect of the intestinal hormone GLP-1 to control insulin secretion in healthy persons and those with diabetes. To do this research volunteers will have insulin levels measured after meals on two occasions. The effect of GLP-1 will be determined by giving a blocker of GLP-,1 called exendin-(9-39, in one of the studies. By comparing insulin secretion with and without GLP-1 blockade, the effect of GLP-1 can be estimated from the difference in the two studies.