VARIABILITY BETWEEN INDIVIDUALS WITH RESPECT TO COGNITIVE AND PHYSIOLOGICAL

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。情绪唤醒的问题及其认知后果不仅对大脑有短期的、有时是不可逆转的神经毒性影响。需要更好地了解压力的这些潜在影响，以便将风险降至最低，并最终开发出更好的治疗已经发生的损害的方法。这项研究是研究应激反应的短期和长期影响的关键的第一步，使用跨学科的方法结合最先进的技术，建立急需的关于唤醒下人类表现和神经功能的标准。本研究的主要目的是：a)考察应激反应的神经、心脏和内分泌指标在个体之间的变异性；b)考察生理应激反应是否能准确预测个体对唤醒的认知韧性，通过预先注意和注意利用相关线索和筛选无关线索来衡量；c)阐明在那些最有效地改善唤醒的认知和生理影响的个体中，代偿神经机制所起的作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The problem of emotional arousal and its cognitive consequences not only has short-term,sometimes irreversible ,neuro-toxic effects on the brain. These potential effects of stress need to be better understood both to minimize risk,as well as eventually to develop better treatment for damage that has already occurred. This study constitutes a critical first step in investigating both short and long-term effects of stress reactivity, using an inter-disciplinary approach combined with state of the art technology, to establish much needed norms on human performance and neurological function under arousal. The primary aims of this study are to: a) examine variability between individuals on neural,cardiac,and endocrine measures of stress reactivity; b) to investigate whether,for each individual,physiological stress reactivity accurately predicts that individual's cognitive resilience to arousal,as measured by pre-attentive and attentive utilization of relevant cues and screening of irrelevant cues; and c) to elucidate the role of compensatory neural mechanisms in those individuals who are most efficient at ameliorating the cognitive and physiological effects of arousal.