ASSESSMENT OF LIVER FUNCTION IN PATIENTS UNDERGOING HEPATIC IRRADIATION

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项研究正在进行评估使用吲哚菁绿（IC-Green）来确定放射过程中的肝功能。我们相信，如果我们能更好地估计个体的毒性风险，那么在并发症发生之前，辐射就可以在并发症高风险的患者中停止。参加这项研究的受试者必须年满18岁。不会因性别、民族或种族而加以排斥。孕妇将被排除在外。这项研究正在进行评估使用吲哚菁绿（IC-Green）来确定放射过程中的肝功能。我们相信，如果我们能更好地估计个体的毒性风险，那么在并发症发生之前，辐射就可以在并发症高风险的患者中停止。参加这项研究的受试者必须年满18岁。不会因性别、民族或种族而加以排斥。孕妇将被排除在外。参加这项研究的患者需要接受肝脏放射治疗。为了这项研究的目的，他们将在放射治疗开始前两周内接受IC-GREEN测试，大约20-27 Gy，大约40-54 Gy，大约在放射后一个月，大约在放射后两个月。静脉注射IC-Green后5分钟，10分钟，15分钟和20分钟采集血样。该试验的目的是通过IC-Green提取来评估放射治疗对肝功能的影响。研究人员认为，如果他们能够确定患者接受肝脏放射治疗可能产生严重副作用的可能性，那么在并发症发生之前，那些风险最高的患者就可以停止放射治疗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is being conducted to assess the use of indocyanine green (IC-Green) to determine liver function during a course of radiation. The belief is that if we can better estimate the risk of toxicity on an individual basis that radiation can be stopped in patients at high risk for complications before the complications occur. Subjects who take part in this research must be 18 or older. No exclusion will be made based on gender, ethnicity or race. Pregnant women will be excluded from participating. This research is being conducted to assess the use of indocyanine green (IC-Green) to determine liver function during a course of radiation. The belief is that if we can better estimate the risk of toxicity on an individual basis that radiation can be stopped in patients at high risk for complications before the complications occur. Subjects who take part in this research must be 18 or older. No exclusion will be made based on gender, ethnicity or race. Pregnant women will be excluded from participating. Patients who take part in this study are required to be scheduled for radiation to the liver. For the purposes of this research, they will undergo IC-GREEN testing within 2 weeks prior to the start of radiation therapy, at approximately 20-27 Gy, at approximately 40-54 Gy, approximately one month after radiation, and approximately two months after radiation. Blood samples will be collected at 5, 10, 15, and 20 minutes following I.V. administration of IC-Green. The goal of the trial is to assess the effect of radiation treatment on liver function as determined by IC-Green extraction. The researchers believe that if they can determine the chances that a patient getting radiation to the liver might experience severe side effects that the radiation can be stopped in those patients at highest risk before the complications occur.