ASSESSMENT OF LIVER FUNCTION IN PATIENTS UNDERGOING HEPATIC IRRADIATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 这项研究正在进行，以评估使用吲哚菁绿色（IC-绿色），以确定肝功能在一个过程中的辐射。我们的信念是，如果我们能够更好地估计个体基础上的毒性风险，就可以在并发症发生之前停止高风险并发症患者的放射治疗。参加本研究的受试者必须年满18岁。不会基于性别、种族或人种进行排除。孕妇将被排除在参与之外。这项研究正在进行，以评估使用吲哚菁绿色（IC-绿色），以确定肝功能在一个过程中的辐射。我们的信念是，如果我们能够更好地估计个体基础上的毒性风险，就可以在并发症发生之前停止高风险并发症患者的放射治疗。参加本研究的受试者必须年满18岁。不会基于性别、种族或人种进行排除。孕妇将被排除在参与之外。参加本研究的患者需要安排肝脏放射治疗。出于本研究的目的，他们将在放射治疗开始前2周内、约20-27戈伊、约32-54戈伊、放射治疗后约1个月和放射治疗后约2个月接受IC-GREEN测试。将在基线0、静脉注射IC-Green后5、10、15和20分钟采集血样。本试验的目的是评估放射治疗对肝功能的影响，通过IC-绿提取测定。研究人员认为，如果他们能够确定患者接受肝脏放射治疗可能会出现严重副作用的可能性，那么在并发症发生之前，这些风险最高的患者可以停止放射治疗。'

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research is being conducted to assess the use of indocyanine green (IC-Green) to determine liver function during a course of radiation. The belief is that if we can better estimate the risk of toxicity on an individual basis that radiation can be stopped in patients at high risk for complications before the complications occur. Subjects who take part in this research must be 18 or older. No exclusion will be made based on gender, ethnicity or race. Pregnant women will be excluded from participating. This research is being conducted to assess the use of indocyanine green (IC-Green) to determine liver function during a course of radiation. The belief is that if we can better estimate the risk of toxicity on an individual basis that radiation can be stopped in patients at high risk for complications before the complications occur. Subjects who take part in this research must be 18 or older. No exclusion will be made based on gender, ethnicity or race. Pregnant women will be excluded from participating. Patients who take part in this study are required to be scheduled for radiation to the liver. For the purposes of this research, they will undergo IC-GREEN testing within 2 weeks prior to the start of radiation therapy, at approximately 20-27 Gy, at approximately 32-54 Gy, approximately one month after radiation, and approximately two months after radiation. Blood samples will be collected baseline 0, at 5, 10, 15, and 20 minutes following I.V. administration of IC-Green. The goal of the trial is to assess the effect of radiation treatment on liver function as determined by IC-Green extraction. The researchers believe that if they can determine the chances that a patient getting radiation to the liver might experience severe side effects that the radiation can be stopped in those patients at highest risk before the complications occur.'