INCREASED ALPHA1-ADRENOCEPTOR-MEDIATED PRESSOR SENSITIVITY & CHRONIC RENAL DIS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是进一步了解为什么大多数肾病早期患者的血压会升高。我们想要确定导致肾病患者高血压的因素之一是否是血管收缩增加或有助于控制血压的中枢神经系统反射异常。此外，我们还想确定增加血液中的脂肪酸(一种脂肪)是否会影响血管收缩和血压反射。更多关于高血压与肾脏疾病相关的知识可能会导致更好的治疗，并有助于预防肾脏疾病患者的心脏病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to further understand why blood pressure is elevated in most patients with early stages of kidney disease. We want to determine whether one of the factors responsible for high blood pressure in people with kidney disease is increased constriction of blood vessels or abnormalities in central nervous system reflexes which help to control blood pressure. In addition, we want to determine whether raising fatty acids (a type of fat) in the bloodstream influences blood vessel constriction and blood pressure reflexes. More knowledge about high blood pressure related to kidney disease may lead to better treatment and help to prevent heart disease in people with kidney disease.