RETINOPATHY IN CHRONIC RENAL INSUFFICIENCY (RCRIC)

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 目的： CRIC（RCRIC）视网膜病变研究是慢性肾功能不全队列（CRIC）研究的附加研究。RCRIC旨在研究视网膜（眼睛后部）疾病（称为视网膜病变）和肾脏疾病之间的关系。在获得书面知情同意后，研究人员将使用专用相机拍摄一组视网膜眼底照片。本研究将招募并进行为期2年的测试。这些照片中的信息将与审评委母研究中正在收集的数据相联系，以解决以下假设： 假设1.视网膜病变（眼病）是肾脏疾病进展和发展为终末期肾脏疾病的危险因素 具体目标1：确定眼病和肾病与终末期肾病发展之间的关系 假设2.视网膜病变（眼部疾病）是心血管疾病的危险因素。 具体目标2：确定眼部疾病与心血管事件和心血管疾病进展之间的关系 这项研究的结果有可能1）提供关于视网膜病变，肾脏和心血管疾病之间关系的新见解。2)提供了一种新的非侵入性方法来评估肾脏和心血管疾病预后不良的高风险患者。'

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Purpose: Retinopathy in CRIC (RCRIC) Study is an additional study to the Chronic Renal Insufficiency Cohort (CRIC) Study. The RCRIC is designed to investigate the relationship between diseases of the retina (back of the eye) called retinopathy and kidney disease. After written informed consent, participants will have one set of retinal fundus photographs taken with a specialized camera by research staff. This study will recruit and perform tests over a 2-year period. The information from these photographs will be linked to on-going data collection from the parent CRIC Study to address the following hypotheses: Hypothesis 1. Retinopathy (eye disease) is a risk factor for the progression of kidney disease and development of end-stage renal disease Specific Aim 1: Determine the relationship between eye disease and kidney disease and development of end-stage renal disease Hypothesis 2. Retinopathy (eye disease) is a risk factor for cardiovascular disease. Specific Aim 2: Determine the relationship between eye disease and cardiovascular events and cardiovascular disease progression The results from this study have the potential to 1) provide new insights about the relationship between retinopathy, kidney and cardiovascular disease. 2) provide a novel non-invasive method to assess patients at high risk for poor outcomes in both kidney and cardiovascular disease.'