PULSE WAVE ANALYSIS IN CRIC

CRI 中的脉冲波分析

• 批准号: 7603810
• 负责人: CRYSTAL A. GADEGBEKU
• 金额: $ 2.35万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603810
• 关键词: Age; Arteries; Blood Pressure; Blood Vessels; Breast; Chronic Kidney Failure; Chronic Kidney Insufficiency; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Data Analyses; Data Coordinating Center; Devices; Electrocardiogram; Funding; Grant; Inguinal region; Institution; Invasive; Localized; Measurement; Measures; Neck; Observational Study; Online Systems; Patients; Pennsylvania; Physiologic pulse; Population; Procedures; Pulse taking; Radial; Research; Research Ethics Committees; Research Personnel; Resources; Rest; Secure; Skin; Source; System; United States National Institutes of Health; Universities; Visit; Wrist; base; bone; cohort; design; indexing; instrument; notch protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This multi-center NIH-sponsored longitudinal observational study is an additional study to the Chronic Renal Insufficiency Cohort (CRIC) study (IRB # 2001-0779) designed to examine vascular stiffness in patients with chronic kidney disease. Based on the CRIC population, subjects will be ethnically and racially diverse and between the ages of 21-74 with mild to moderate chronic kidney disease. During the usual CRIC study visit, additional non-invasive procedures will be done to measure aortic pulse wave velocity and central augmentation index. Blood pressure is measured after 5 minutes rest and three ECG leads are placed on the skin. Carotid (neck artery) pulse is localized and distance from carotid pulse to sternal notch (top of breast bone) is measured. The Atcor PVX device measures pulse wave velocity by obtaining 20 seconds of wave form information using an instrument over the skin near the carotid pulse. Subsequently, the right femoral (groin artery) pulse is localized and distance measured from femoral to navel to sternal notch. Using the same device, the pulse wave velocity is measured at the femoral pulse. The central augmentation index is measured by localizing the right radial (wrist) artery pulse and obtaining ten seconds of wave form information. Approximately 20 minutes are required to obtain all measurements. Subjects will have aortic pulse wave velocity and central augmentation index measured at baseline or year 1 CRIC visit and every other year until 2009. All information, without personal identification, is transferred to University of Pennsylvania on a web-based password-secured and encrypted system to the data coordinating center for data analysis. '

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项多中心NIH申办的纵向观察性研究是慢性肾功能不全队列（CRIC）研究（IRB # 2001-0779）的附加研究，旨在检查慢性肾脏疾病患者的血管硬度。 基于CRIC人群，受试者将在人种和种族上多样化，年龄在21-74岁之间，患有轻度至中度慢性肾脏疾病。 在常规CRIC研究访视期间，将进行额外的无创程序，以测量主动脉脉搏波速度和中心增强指数。 休息5分钟后测量血压，并将三个ECG导联置于皮肤上。 定位颈动脉（颈动脉）脉搏，并测量颈动脉脉搏到胸骨切迹（胸骨顶部）的距离。 Atcor PVX器械通过在颈动脉脉搏附近的皮肤上使用仪器获得20秒的波形信息来测量脉搏波速度。 随后，定位右股动脉（腹股沟动脉）脉搏，并测量从股动脉到脐动脉到胸骨切迹的距离。 使用相同的装置，在股动脉脉搏处测量脉搏波速度。 通过定位右桡（腕）动脉脉搏并获得10秒的波形信息来测量中心增强指数。 大约需要20分钟才能获得所有测量结果。 受试者将在基线或第1年CRIC访视时测量主动脉脉搏波速度和中心增强指数，并每隔一年测量一次，直至2009年。 所有信息，没有个人身份，被转移到宾夕法尼亚大学基于网络的密码保护和加密系统的数据协调中心进行数据分析。 '