EFFECTS OF OBSTRUCTIVE SLEEP APNEA & TREATMENT ON PERSISTENT ASTHMA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。哮喘是一种常见的慢性炎症性肺部疾病，在发病率、生活质量和医疗费用方面给我们的社会带来了越来越大的负担。尽管我们对哮喘病因和治疗的理解取得了重大进展，但一些哮喘患者的症状持续存在，生活质量很差。阻塞性睡眠呼吸暂停（睡眠时停止呼吸）也是一种常见疾病。与睡眠相关的抱怨在哮喘患者中很常见，但没有研究表明阻塞性睡眠呼吸暂停（OSA）在持续性哮喘（PA）患者中有多频繁。持续气道正压通气（CPAP）治疗OSA对哮喘控制的改善程度也不清楚。我们建议进行一项研究，通过进行夜间睡眠研究，评估在PA患者样本中发现OSA的频率，这些患者经常出现睡眠相关的抱怨，提示OSA（如打鼾，睡眠时呼吸停止和白天嗜睡）。我们将尝试确定持续气道正压（CPAP）治疗8周对哮喘控制、生活质量和健康资源利用的影响。此外，我们将评估可能将睡眠障碍与哮喘症状的发作和使用CPAP治疗8周后血液炎症标志物变化联系起来的机制。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Asthma is a common chronic inflammatory lung condition that imposes a growing burden to our society in terms of morbidity, quality of life and healthcare costs. Despite significant progress in our understanding of asthma causes and treatment, some asthmatics have persistent symptoms and have a poor quality of life. Obstructive sleep apnea (stopping breathing while sleeping) is also a common condition. Sleep related complaints are common among asthmatics, but there are no studies to show how frequent obstructive sleep apnea (OSA) is among patients with persistent asthma (PA). The magnitude of improvement in asthma control achieved by treatment of OSA with continuous positive airway pressure (CPAP) is not known either. We propose a study to assess how frequently OSA is found in a sample of patients with PA and frequent sleep related complains suggestive of OSA (such as snoring, witnessed episodes of stopping breathing while asleep and daytime sleepiness), by performing nocturnal sleep studies. We will try to determine the impact of 8-week of continuous positive airway pressure (CPAP) treatment on asthma control, quality of life and health resources utilization. Also, we will evaluate mechanisms that may link sleep disturbances to the onset of asthma symptoms and changes in blood inflammatory markers after 8-week therapy with CPAP.