CHARACTERIZATION OF OPIOID PHARMACODYNAMICS AND SIDE EFFECTS IN ELDERLY

阿片类药物药效学特征和老年人副作用

• 批准号: 7379354
• 负责人: MONIQUE CHERRIER
• 金额: $ 1.32万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379354
• 关键词: CHARACTERIZATION; OPIOID; PHARMACODYNAMICS; SIDE; EFFECTS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Persistent pain, sufficient to cause significant impairment in daily functioning affects up to 50 percent of older adults. Analgesics are the most common therapy used to manage pain, with opioids playing an increasingly important role in the treatment of chronic disabling pain in older adults. The efficacy of opioid therapy needs to be balanced against potential side effects, including the risk of neurocognitive impairment. To date, no studies have examined the effects of opioids on the neurocognitive function of older adults.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。持续性疼痛，足以导致日常功能的严重损害，影响高达50%的老年人。镇痛药是最常用的疼痛治疗方法，阿片类药物在老年人慢性致残性疼痛的治疗中发挥着越来越重要的作用。阿片类药物治疗的疗效需要与潜在的副作用（包括神经认知障碍的风险）相平衡。到目前为止，还没有研究检查阿片类药物对老年人神经认知功能的影响。