Assessment of Cognitive & Mood Effects from ADT in Men with Prostate Cancer

认知评估

• 批准号: 7630434
• 负责人: MONIQUE CHERRIER
• 金额: $ 21.81万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-07 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7630434
• 关键词: Adjuvant; Affect; Aftercare; Androgen Suppression; Androgens; Anemia; Area; Attention; Back; Biochemical; Body mass index; Bone Density; Brain region; Breast; Cancer Control; Cancer Survivor; Climacteric; Clinical Trials; Cognition; Cognitive; Control Groups; Disease; Emotional; Emotional Stress; Fred Hutchinson Cancer Research Center; Future; Goals; Gynecomastia; Hair; Health Personnel; Health Professional; Impaired cognition; Incidence; Intervention; Knowledge; Laboratories; Life; Lipids; Literature; Lung; Malignant neoplasm of prostate; Metastatic Prostate Cancer; Methods; Moods; Motivation; Muscular Atrophy; Nature; Nurses; Obesity; Operative Surgical Procedures; Pacific Northwest; Participant; Patient Recruitments; Patients; Physiological; Positioning Attribute; Prospective Studies; Prostate Cancer therapy; Quality of life; Radiation; Relapse; Reporting; Reproduction spores; Research Design; Research Personnel; Residual state; Resources; Sampling; Serum; Sex Functioning; Staging; Supplementation; Survivors; Symptoms; System; Techniques; Testosterone; Therapeutic; Time; Universities; Washington; base; biobehavior; cancer care; cancer diagnosis; chemotherapy; cognitive change; comparison group; depressed; deprivation; design; emotional distress; executive function; experience; men; novel; programs; psychosocial; single episode major depressive disorder

DESCRIPTION (provided by applicant): Prostate cancer is the most common form of cancer diagnosed in men. Despite better surgical and radiation techniques, approximately 40% of men will relapse after primary therapy and many will undergo Androgen deprivation therapy (ADT). Long-term physiological consequences of androgen deprivation can include obesity, anemia, loss of bone mineral density, muscle atrophy, alterations of serum lipids, loss of body hair, gynecomastia as well as mood and cognitive changes. Our laboratory as well as others have reported that men undergoing ADT experience depressed and anxious mood, low energy and cognitive decrements. Because cognitive decrements and mood symptoms have been reported among other cancer survivors (e.g. breast, lung), it is unclear whether these changes from ADT are related to the loss of androgens, residual effects from chemotherapy and/or radiation or from the stress and emotional effects of dealing with a life-threatening illness or an interaction of these factors. This project will assess the cognitive, emotional and quality of life changes in men with non-metastatic prostate cancer who are treated on a clinical trial of intermittent androgen suppression (IAS). The study will also bring the testosterone back to physiological levels at a predictable time after stopping ADT. Use of the "off-on-off1 design will allow an examination of intra-patient changes. The proposed study will also compare the ADT treated patients to a prostate cancer control group (non-metastatic) matched for duration since primary treatment for between group comparisons. Increasing our understanding of the incidence and nature of cognitive, mood and quality-of-life changes from ADT, may help health care professionals better recognize and treat mood and cognitive changes from ADT as well as informing patients of what to expect prior to treatment. A prospective study of psychosocial and cognitive factors of ADT with an appropriate control group represents a large contribution to the body of knowledge with regard to prostate cancer.

描述（由申请人提供）：前列腺癌是男性诊断的最常见的癌症形式。尽管采用了更好的手术和辐射技术，但大约40％的男性将在初级治疗后复发，许多男性将接受雄激素剥夺治疗（ADT）。雄激素剥夺的长期生理后果可能包括肥胖，贫血，骨矿物质密度的损失，肌肉萎缩，血清脂质的改变，身体毛的丧失，妇科症，情绪和认知改变。我们的实验室以及其他人都报告说，经历ADT的男性经历沮丧和焦虑的情绪，低能量和认知能力的降低。由于在其他癌症幸存者（例如乳腺癌，肺）中已经报道了认知能力减少和情绪症状，因此尚不清楚ADT的这些变化是否与雄激素的丧失，化学疗法和/或放射线的残留作用有关，或者对与生命的疾病或这些因素相互作用的压力和情绪影响。该项目将评估非转移性前列腺癌男性的认知，情感和生活质量变化，这些变化在间歇性雄激素抑制（IAS）的临床试验中接受治疗。这项研究还将在停止ADT后的可预测时间将睾丸激素恢复到生理水平。 Use of the "off-on-off1 design will allow an examination of intra-patient changes. The proposed study will also compare the ADT treated patients to a prostate cancer control group (non-metastatic) matched for duration since primary treatment for between group comparisons. Increasing our understanding of the incidence and nature of cognitive, mood and quality-of-life changes from ADT, may help health care professionals better recognize and treat mood and cognitive changes from ADT as well as informing patients of在治疗之前将期望对ADT的心理和认知因素进行适当的对照组的前瞻性研究，这代表了对前列腺癌的知识的巨大贡献。