Assessment of Cognitive & Mood Effects from ADT in Men with Prostate Cancer

认知评估

• 批准号: 8082779
• 负责人: MONIQUE CHERRIER
• 金额: $ 21.19万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-07 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8082779
• 关键词: Adjuvant; Affect; Aftercare; Androgen Suppression; Androgens; Anemia; Area; Attention; Back; Biochemical; Body mass index; Bone Density; Brain region; Breast; Cancer Control; Cancer Survivor; Climacteric; Clinical Trials; Cognition; Cognitive; Control Groups; Depressed mood; Disease; Emotional; Emotional Stress; Fred Hutchinson Cancer Research Center; Future; Goals; Gynecomastia; Hair; Health Personnel; Health Professional; Impaired cognition; Incidence; Intervention; Knowledge; Laboratories; Life; Lipids; Literature; Lung; Malignant neoplasm of prostate; Methods; Moods; Motivation; Muscular Atrophy; Nature; Nurses; Obesity; Operative Surgical Procedures; Pacific Northwest; Participant; Patient Recruitments; Patients; Physiological; Positioning Attribute; Prospective Studies; Quality of life; Radiation; Relapse; Reporting; Research Design; Research Personnel; Residual state; Resources; Sampling; Serum; Sex Functioning; Staging; Supplementation; Survivors; Symptoms; System; Techniques; Testosterone; Therapeutic; Time; Universities; Washington; base; biobehavior; cancer care; cancer diagnosis; chemotherapy; cognitive change; comparison group; deprivation; design; disturbance in affect; emotional distress; executive function; experience; men; novel; programs; psychosocial; single episode major depressive disorder

DESCRIPTION (provided by applicant): Prostate cancer is the most common form of cancer diagnosed in men. Despite better surgical and radiation techniques, approximately 40% of men will relapse after primary therapy and many will undergo Androgen deprivation therapy (ADT). Long-term physiological consequences of androgen deprivation can include obesity, anemia, loss of bone mineral density, muscle atrophy, alterations of serum lipids, loss of body hair, gynecomastia as well as mood and cognitive changes. Our laboratory as well as others have reported that men undergoing ADT experience depressed and anxious mood, low energy and cognitive decrements. Because cognitive decrements and mood symptoms have been reported among other cancer survivors (e.g. breast, lung), it is unclear whether these changes from ADT are related to the loss of androgens, residual effects from chemotherapy and/or radiation or from the stress and emotional effects of dealing with a life-threatening illness or an interaction of these factors. This project will assess the cognitive, emotional and quality of life changes in men with non-metastatic prostate cancer who are treated on a clinical trial of intermittent androgen suppression (IAS). The study will also bring the testosterone back to physiological levels at a predictable time after stopping ADT. Use of the "off-on-off1 design will allow an examination of intra-patient changes. The proposed study will also compare the ADT treated patients to a prostate cancer control group (non-metastatic) matched for duration since primary treatment for between group comparisons. Increasing our understanding of the incidence and nature of cognitive, mood and quality-of-life changes from ADT, may help health care professionals better recognize and treat mood and cognitive changes from ADT as well as informing patients of what to expect prior to treatment. A prospective study of psychosocial and cognitive factors of ADT with an appropriate control group represents a large contribution to the body of knowledge with regard to prostate cancer.

描述（由申请人提供）：前列腺癌是男性中最常见的癌症。尽管有更好的手术和放射技术，大约40%的男性在初次治疗后会复发，许多人将接受雄激素剥夺治疗（ADT）。雄激素剥夺的长期生理后果可包括肥胖、贫血、骨矿物质密度损失、肌肉萎缩、血脂改变、体毛损失、男性乳房发育以及情绪和认知变化。我们的实验室和其他实验室都报告说，接受ADT的男性会经历抑郁和焦虑情绪，低能量和认知能力下降。由于在其他癌症幸存者（例如乳腺癌、肺癌）中报告了认知减退和情绪症状，因此尚不清楚ADT的这些变化是否与雄激素丢失、化疗和/或放疗的残留效应或处理危及生命的疾病的压力和情绪效应或这些因素的相互作用有关。该项目将评估接受间歇性雄激素抑制（IAS）临床试验治疗的非转移性前列腺癌男性的认知、情感和生活质量变化。该研究还将在停止ADT后的可预测时间内使睾酮恢复到生理水平。使用“关-开-关1”设计将允许检查患者内变化。拟定研究还将比较ADT治疗患者与自主要治疗以来持续时间匹配的前列腺癌对照组（非转移性），以进行组间比较。增加我们对ADT引起的认知、情绪和生活质量变化的发生率和性质的了解，可能有助于医疗保健专业人员更好地识别和治疗ADT引起的情绪和认知变化，并告知患者治疗前的预期。一项关于ADT的心理社会和认知因素的前瞻性研究与一个适当的对照组代表了对前列腺癌知识体系的巨大贡献。

项目成果

A randomized trial of cognitive rehabilitation in cancer survivors.

• DOI: 10.1016/j.lfs.2013.08.011
• 发表时间: 2013-10-17
• 期刊: LIFE SCIENCES
• 影响因子: 6.1
• 作者: Cherrier, M. M.;Anderson, K.;David, D.;Higano, C. S.;Gray, H.;Church, A.;Willis, S. L.
• 通讯作者: Willis, S. L.