INSULIN SENSITIVITY, HEMODYNAMICS AND ENDOTHELIAL FUNCTION IN WOMAN

女性胰岛素敏感性、血流动力学和内皮功能

• 批准号: 7379312
• 负责人: DARCY R CARR
• 金额: $ 2.65万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379312
• 关键词: INSULIN; SENSITIVITY; HEMODYNAMICS; ENDOTHELIAL; FUNCTION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Preeclampsia, a hypertensive disorder unique to pregnancy, is leading cause of maternal and neonatal morbidity and mortality. Endothelial dysfunction is a central feature in the pathophysiology of preeclampsia and mechanisms that have been suggested to contribute to the endothelial dysfunction include hyperinsulinenmia, dyslipidemia, and high cardiac output. Insulin resistance and high cardiac output persist postpartum, suggesting that these women have an underlying disorder. It is unknown whether there is persistence of other features commonly associated with the insulin resistance syndrome and whether these features are linked and contribute to endothelial dysfunction. Thus, the specific aims of this proposal are: 1) Evaluate postpartum women with a history of preeclampsia for features of the insulin resistance syndrome that are thought to contribute to endothelial dysfunction, and 2) Explore the relationships between insulin resistance and these identified features by evaluating for improvement in these abnormalities after insulin resistance is ameliorated with an insulin sensitizing agent. A case-control study, designed to examine specific aim 1, will address the hypothesis that postpartum women with a history of preeclampsia are insulin resistant and have features of the insulin resistance syndrome (central adiposity, dyslipidemia, elevated cardiac output, and decreased endothelial dependent vasodilation) as compared to women without a history of preeclampsia.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。先兆子痫是妊娠期特有的高血压疾病，是导致孕产妇和新生儿发病和死亡的主要原因。内皮功能障碍是先兆子痫的病理生理学的中心特征，并且已经表明导致内皮功能障碍的机制包括高胰岛素血症、血脂异常和高心输出量。产后胰岛素抵抗和高心输出量持续存在，表明这些妇女有潜在的疾病。目前尚不清楚是否存在与胰岛素抵抗综合征相关的其他特征，以及这些特征是否与内皮功能障碍相关并导致内皮功能障碍。因此，本提案的具体目的是：1）评价有先兆子痫病史的产后妇女的胰岛素抵抗综合征的特征，这些特征被认为有助于内皮功能障碍，和2）通过评价用胰岛素增敏剂改善胰岛素抵抗后这些异常的改善，探索胰岛素抵抗与这些已鉴定特征之间的关系。一项病例对照研究，旨在检查具体目标1，将解决以下假设：与无先兆子痫病史的女性相比，有先兆子痫病史的产后女性具有胰岛素抵抗，并具有胰岛素抵抗综合征的特征（中枢性肥胖、血脂异常、心输出量升高和内皮依赖性血管舒张功能降低）。