INSULIN SENSITIVITY, HEMDYNAMICS AND ENDOTHELIAL FUNCTION IN WOMAN
INSULIN SENSITIVITY, HEMDYNAMICS AND ENDOTHELIAL FUNCTION IN WOMAN
批准号:
7603430
负责人:
DARCY R CARR
金额:
$0.16万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2007
资助国家:
美国
项目状态:
已结题
起止时间:
2007-04-01 至 2007-09-16
关键词:
AddressCardiac OutputComputer Retrieval of Information on Scientific Projects DatabaseCross-Over StudiesCross-Sectional StudiesDiseaseDouble-Blind MethodDyslipidemiasFunctional disorderFundingGrantHigh Cardiac OutputInstitutionInsulinInsulin ResistanceLinkMeasurementMetabolic syndromeObesityPostpartum PeriodPostpartum WomenPre-EclampsiaPregnancyRecording of previous eventsResearchResearch DesignResearch PersonnelResourcesSourceThinkingUnited States National Institutes of HealthVasodilationWomaninsulin sensitivitymortalityneonatal morbidityrandomized placebo controlled trialrosiglitazone
中文摘要
这个子项目是众多研究子项目之一
英文摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Pre-eclampsia, a hypertensive disorder unique to pregnancy, is leading cause of maternal and neonatal morbidity and mortality. Endothelial dysfunction is a central feature in the pathophysiology of pre-eclampsia and mechanisms that have been suggested to contribute to the endothelial dysfunction include hyperinsulinenmia, dyslipidemia, and high cardiac output. Insulin resistance and high cardiac output persist postpartum, suggesting that these women have an underlying disorder. It is unknown whether there is persistence of other features commonly associated with the metabolic syndrome and whether these features are linked and contribute to endothelial dysfunction. Thus, the specific aims of this proposal are: 1) Evaluate postpartum women with a history of pre-eclampsia for features of the insulin resistance and the metabolic syndrome that are thought to contribute to endothelial dysfunction, and 2) Explore the relationships between insulin resistance and these identified features by evaluating for improvement in these abnormalities after insulin resistance is ameliorated with an insulin sensitizing agent. A cross-sectional study, designed to examine specific aim 1, will address the hypothesis that postpartum women with a history of pre-eclampsia are insulin resistant and have features of the metabolic syndrome (central adiposity, dyslipidemia, elevated cardiac output, and decreased endothelial dependent vasodilation) as compared to women without a history of pre-eclampsia. A double-blind, placebo-controlled randomized study will address the second hypothesis using an insulin sensitizing agent, rosiglitazone, in a 6 month cross-over study with measurements at baseline, 6 months, and 12 months.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
DOES IMMEDIATE POSTPARTUM GLUCOSE SCREENING PREDICT DIABETES MELLITUS IN WOMEN
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批准号:7603507
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项目类别:
-
资助金额:$0.02万
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财政年份:2007
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负责人:DARCY R CARR
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依托单位:
INSULIN SENSITIVITY, HEMODYNAMICS AND ENDOTHELIAL FUNCTION IN WOMAN
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批准号:7379312
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项目类别:
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资助金额:$2.65万
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财政年份:2006
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负责人:DARCY R CARR
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依托单位:
INSULIN RESISTANCE IN WOMEN WITH A HISTORY OF PREECLAMPSIA
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批准号:7198809
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项目类别:
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资助金额:$3.21万
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财政年份:2005
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负责人:DARCY R CARR
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依托单位:
Insulin resistance in women with history of preeclampsia
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批准号:6974514
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项目类别:
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资助金额:$3.3万
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财政年份:2004
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负责人:DARCY R CARR
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依托单位:
海外基金