DOES IMMEDIATE POSTPARTUM GLUCOSE SCREENING PREDICT DIABETES MELLITUS IN WOMEN

立即进行产后血糖筛查可以预测女性患糖尿病吗

• 批准号: 7603507
• 负责人: DARCY R CARR
• 金额: $ 0.02万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603507
• 关键词: American; Body fat; Clinical; Computer Retrieval of Information on Scientific Projects Database; Detection; Diabetes Mellitus; Diagnosis; Disease; Fasting; Funding; Gestational Diabetes; Glucose; Grant; Hospitals; Hour; Institution; Lead; Life; Morbidity - disease rate; OGTT; Patients; Physicians; Plasma; Postpartum Period; Pregnancy; Research; Research Personnel; Resources; Risk; Screening procedure; Source; Subgroup; Testing; United States National Institutes of Health; Week; Woman; diabetes risk; follow-up; glucose metabolism; improved; mortality

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gestational diabetes mellitus (GDM) complicates approximately 14% of pregnancies. It can lead to significant morbidity and mortality during pregnancy and increases the risk for developing diabetes mellitus later in life. The American Diabetes Association (ADA) recommends that physicians diagnose diabetes using a two hour, 75 gram, oral glucose tolerance test (OGTT) done 6 to 8 weeks postpartum. This is logistically difficult due to the poor compliance with patient follow-up postpartum, and the need for a fasting glucose level prior to the 75 gram glucose load. As a result, many women are undiagnosed and may develop more advanced disease. This study will evaluate an alternative strategy for diagnosing diabetes mellitus postpartum. We hypothesize that an immediate OGTT will give comparable results to an OGTT performed 6-8 weeks postpartum. If we show that they have similar glucose values, then the early OGTT may be a feasible alternative. Since women with GDM would receive the OGTT prior to discharge from the hospital, we hypothesize that this would increase compliance with postpartum testing and could have significant clinical implications by improving the detection of diabetes mellitus in these women. We hypothesize that the OGTT will identify more women at risk of diabetes than the fasting plasma glucose level alone, which would support doing OGTT in clinical practice instead of a fasting glucose level only. We will characterize the changes in glucose metabolism, and body fat between the immediate postpartum period and 6-8 weeks postpartum in a subgroup of women with gestational diabetes.

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