TREATMENTS FOR WHIPLASH-ASSOCIATED DISORDERS (WAD) - BIOBEHAVIORAL APPROACH

颈部扭伤相关疾病 (WAD) 的治疗 - 生物行为方法

• 批准号: 7379317
• 负责人: DENNIS Charles TURK
• 金额: $ 14.97万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7379317
• 关键词: TREATMENTS; WHIPLASH; ASSOCIATED; DISORDERS; WAD

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Over 6.1 million police-reported motor vehicle accidents (MVAs) occurred in the United States in 2000. Whiplash injury is the most common form of injury resulting from an MVA. People prone to negative emotional responses are at risk of experiencing elevated levels of fear and anxiety and consequently may be predisposed to develop Whiplash-Associated Disorders (WADs), the clinical manifestations of whiplash injury. Chronic WADs (those that last longer than 6 months) are extremely resistant to treatment. Little is known about the pathophysiology of chronic WADs due to relatively minor neck injury following MVAs. Early interventions in back pain populations that target reduction of fear and subsequent avoidance of activity have been shown to prevent chronic musculoskeletal pain and disability. Preventing chronicity of WADs using similar interventions, however, has not been explored. The purpose of this clinical trial is to test the efficacy of early, biobehavioral interventions to prevent chronic pain and disability associated with whiplash injuries following an MVA. The study compares the efficacy of two interventions in reducing pain and disability at the subacute stage, thus preventing maintenance of WAD symptoms compared to standard care. We hypothesize that (1) intervention subjects will demonstrate significantly greater reduction of anxiety, pain, and functional limitations than standard care subjects, (2) an intervention using exposure-based anxiety reduction will result in significantly better outcomes than an intervention using educational lectures, and (3) subacute WADs subjects will report significantly greater degrees of anxiety and fear-avoidance than subjects whose symptoms remit within 1 month following the MVA.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。2000年，美国发生了610多万起警方报告的机动车事故。挥鞭样损伤是最常见的由MVA引起的损伤形式。容易产生负面情绪反应的人有可能经历更高水平的恐惧和焦虑，因此可能容易患上挥鞭样损伤相关疾病（WAD），这是挥鞭样损伤的临床表现。慢性WAD（持续时间超过6个月的WAD）对治疗具有极强的抵抗力。由于MVA后颈部损伤相对较小，因此对慢性WAD的病理生理学知之甚少。针对背痛人群的早期干预措施，旨在减少恐惧和随后避免活动，已被证明可以预防慢性肌肉骨骼疼痛和残疾。然而，尚未探索使用类似干预措施预防WAD的慢性化。本临床试验的目的是测试早期生物行为干预的有效性，以预防MVA后与挥鞭样损伤相关的慢性疼痛和残疾。该研究比较了两种干预措施在亚急性期减少疼痛和残疾的有效性，从而与标准治疗相比防止WAD症状的维持。我们假设：（1）干预受试者的焦虑、疼痛和功能限制比标准护理受试者明显减少，（2）使用基于焦虑减少的干预将比使用教育讲座的干预产生更好的结果，和（3）亚急性WAD受试者将报告显著更大程度的焦虑和恐惧-症状在MVA后1个月内缓解的受试者相比，