DOES FLUOXETINE REVERSE THE EFFECTS OF EARLY LIFE STRESS ON THE CNS CRF SYSTEM

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究是SPID 3881的修订案。本研究的目的是确定氟西汀（抗抑郁药）是否逆转早期生活压力的神经生物学后果（例如，儿童虐待），并因此对治疗和预防与压力有关的综合征或亚综合征精神病理学是有效的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is an amendment to SPID 3881. The goal of this study is to determine whether fluoxetine (antidepressant) reverses the neurobiological consequences of early life stress (e.g., child abuse) and, thus, is effective for treatment and prevention of stress-related syndromal or subsyndromal psychopathology.