An Australasian, multi-centre, randomized, double-blind, placebo-controlled trial of the efficacy of fluoxetine in improving functional recovery after acute stroke

一项澳大利亚、多中心、随机、双盲、安慰剂对照试验，探讨氟西汀改善急性中风后功能恢复的功效

• 批准号: nhmrc : 1059094
• 负责人: A/Pr Christopher Etherton-Beer
• 金额: $ 153.79万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/an-australasian-multi-acute-stroke/454728
• 关键词: Australasian; multi; centre; randomized; double

Stroke is one of the top three causes of disability. Treatments that improve recovery after stroke are lacking. We reviewed the world literature and found a number of very small studies which, together, suggest that the antidepressant drug, fluoxetine, may improve the recovery in stroke patients. AFFINITY is a large trial in 1600 Australians and New Zealanders with stroke which aims to find out whether taking fluoxetine for 6 months after a stroke improves recovery compared to a placebo.

中风是导致残疾的三大原因之一。缺乏改善中风后恢复的治疗方法。我们回顾了世界文献，发现了一些非常小的研究，这些研究共同表明抗抑郁药氟西汀可以改善中风患者的恢复。AFFINITY是一项在1600名澳大利亚和新西兰中风患者中进行的大型试验，旨在确定与安慰剂相比，中风后服用氟西汀6个月是否能改善恢复。