PREDICTION OF CARDIOMYOPATHY IN TYPE I DIABETES BY 31 P MRS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。具体而言，我们将检验以下假设：糖尿病患者将表现出可逆的、运动诱导的PCr/ATP和PCr/无机磷酸盐降低，这与能量供需失衡一致。此外，我们建议这些变化将只存在于那些糖尿病患者的全身微血管疾病的证据，并将伴随着收缩功能障碍的证据，通过电影MRI评估。最后，我们预计代谢和功能异常的观察将预测短期和长期的结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specifically we will test the hypothesis that patients with diabetes will exhibit reversible, exercise-induced decreases in PCr/ATP and PCr/inorganic phosphate consistent with an imbalance in energy supply and demand. Furthermore, we propose that these changes will be present only in those diabetic patients with evidence of systemic microvascular disease and will be accompanied by evidence of contractile dysfunction as assessed by cine MRI. Finally, we anticipate that the observation of metabolic and functional abnormalities will be predictive of short-and long-term outcomes.