PREDICTION OF CARDIOMYOPATHY IN TYPE I DIABETES BY 31 P MRS

通过 31 P MRS 对 I 型糖尿病心肌病的预测

• 批准号: 7368207
• 负责人: GERALD Michael POHOST
• 金额: $ 2.5万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7368207
• 关键词: PREDICTION; CARDIOMYOPATHY; TYPE; DIABETES; 31

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specifically we will test the hypothesis that patients with diabetes will exhibit reversible, exercise-induced decreases in PCr/ATP and PCr/inorganic phosphate consistent with an imbalance in energy supply and demand. Furthermore, we propose that these changes will be present only in those diabetic patients with evidence of systemic microvascular disease and will be accompanied by evidence of contractile dysfunction as assessed by cine MRI. Finally, we anticipate that the observation of metabolic and functional abnormalities will be predictive of short-and long-term outcomes.

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。具体地说，我们将检验这样一种假设，即糖尿病患者将表现出可逆的、运动诱导的与能量供需失衡相一致的PCRATP和PCR无机磷的减少。此外，我们认为这些改变只会出现在那些有全身性微血管疾病证据的糖尿病患者中，并将伴随着电影MRI评估的收缩功能障碍的证据。最后，我们预计，对代谢和功能异常的观察将预测短期和长期结果。