PREDICTION OF CARDIOMYOPATHY IN TYPE I DIABETES BY 31 P MRS

通过 31 P MRS 对 I 型糖尿病心肌病的预测

• 批准号: 7982103
• 负责人: GERALD Michael POHOST
• 金额: $ 1.39万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7982103
• 关键词: Cardiomyopathies; Cine Magnetic Resonance Imaging; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diabetic Angiopathies; Energy Supply; Exercise; Exhibits; Functional disorder; Funding; Grant; Institution; Insulin-Dependent Diabetes Mellitus; Metabolic; Outcome; Patients; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; diabetic patient; inorganic phosphate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specifically we will test the hypothesis that patients with diabetes will exhibit reversible, exercise-induced decreases in PCr/ATP and PCr/inorganic phosphate consistent with an imbalance in energy supply and demand. Furthermore, we propose that these changes will be present only in those diabetic patients with evidence of systemic microvascular disease and will be accompanied by evidence of contractile dysfunction as assessed by cine MRI. Finally, we anticpate that the observation of metabolic and functional abnormalities will be predictive of short-and long-term outcomes.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 具体来说，我们将检验这样的假设：糖尿病患者将表现出可逆的、运动引起的 PCr/ATP 和 PCr/无机磷酸盐下降，这与能量供需失衡一致。 此外，我们建议这些变化仅出现在那些有全身微血管疾病证据的糖尿病患者中，并且伴随着通过电影 MRI 评估的收缩功能障碍的证据。 最后，我们预计代谢和功能异常的观察将预测短期和长期结果。