PREDICTION OF CARDIOMYOPATHY IN TYPE I DIABETES BY 31 P MRS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体地说，我们将检验这样一种假设，即糖尿病患者将表现出可逆的、运动诱导的与能量供需失衡相一致的PCRATP和PCR无机磷的减少。此外，我们认为这些改变只会出现在那些有全身性微血管疾病证据的糖尿病患者中，并将伴随着电影MRI评估的收缩功能障碍的证据。最后，我们反对对代谢和功能异常的观察将预测短期和长期结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specifically we will test the hypothesis that patients with diabetes will exhibit reversible, exercise-induced decreases in PCr/ATP and PCr/inorganic phosphate consistent with an imbalance in energy supply and demand. Furthermore, we propose that these changes will be present only in those diabetic patients with evidence of systemic microvascular disease and will be accompanied by evidence of contractile dysfunction as assessed by cine MRI. Finally, we anticpate that the observation of metabolic and functional abnormalities will be predictive of short-and long-term outcomes.