PREDICTION OF CARDIOMYOPATHY IN TYPE I DIABETES BY 31 P MRS

通过 31 P MRS 对 I 型糖尿病心肌病的预测

• 批准号: 7716686
• 负责人: GERALD Michael POHOST
• 金额: $ 4.09万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-20 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716686
• 关键词: Cardiomyopathies; Cine Magnetic Resonance Imaging; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diabetic Angiopathies; Energy Supply; Exercise; Exhibits; Functional disorder; Funding; Grant; Institution; Metabolic; Outcome; Patients; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; diabetic; inorganic phosphate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specifically we will test the hypothesis that patients with diabetes will exhibit reversible, exercise-induced decreases in PCr/ATP and PCr/inorganic phosphate consistent with an imbalance in energy supply and demand. Furthermore, we propose that these changes will be present only in those diabetic patients with evidence of systemic microvascular disease and will be accompanied by evidence of contractile dysfunction as assessed by cine MRI. Finally, we anticpate that the observation of metabolic and functional abnormalities will be predictive of short-and long-term outcomes.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 具体而言，我们将检验以下假设：糖尿病患者将表现出可逆的，运动引起的PCR/ATP和PCR/无机磷酸盐降低，这与能源供应和需求不平衡一致。 此外，我们建议只有那些具有全身微血管疾病证据的糖尿病患者中才会存在这些变化，并将伴有Cine MRI评估的收缩功能障碍的证据。 最后，我们抗议代谢和功能异常的观察将预测短期和长期结局。