PREDICTION OF CARDIOMYOPATHY IN TYPE I DIABETES BY 31 P MRS

通过 31 P MRS 对 I 型糖尿病心肌病的预测

• 批准号: 7716686
• 负责人: GERALD Michael POHOST
• 金额: $ 4.09万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-20 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7716686
• 关键词: Cardiomyopathies; Cine Magnetic Resonance Imaging; Computer Retrieval of Information on Scientific Projects Database; Diabetes Mellitus; Diabetic Angiopathies; Energy Supply; Exercise; Exhibits; Functional disorder; Funding; Grant; Institution; Metabolic; Outcome; Patients; Research; Research Personnel; Resources; Source; Testing; United States National Institutes of Health; diabetic; inorganic phosphate

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specifically we will test the hypothesis that patients with diabetes will exhibit reversible, exercise-induced decreases in PCr/ATP and PCr/inorganic phosphate consistent with an imbalance in energy supply and demand. Furthermore, we propose that these changes will be present only in those diabetic patients with evidence of systemic microvascular disease and will be accompanied by evidence of contractile dysfunction as assessed by cine MRI. Finally, we anticpate that the observation of metabolic and functional abnormalities will be predictive of short-and long-term outcomes.

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