METABOLISM OF ANTIEPILEPTIC DRUGS

抗癫痫药物的代谢

• 批准号: 7376373
• 负责人: Page Buckhannan Pennell
• 金额: $ 0.84万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7376373
• 关键词: METABOLISM; ANTIEPILEPTIC; DRUGS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study seeks to characterize the effects of advancing age, gender, and race on carbamazepine (CBZ) pharmacokinetics and metabolism utilizing an IV dose of a stable-labeled CBZ isotope. This study will also seek to determine if subjects homozygous or heterozygous for the CYP3A5*1 allele have an increased CBZ clearance and a faster elimination half-life.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。本研究旨在通过静脉注射稳定标记的卡马西平（CBZ）同位素，研究年龄、性别和种族对CBZ药代动力学和代谢的影响。本研究还将试图确定CYP 3A 5 *1等位基因纯合子或杂合子受试者是否具有增加的CBZ清除率和更快的消除半衰期。