ARTHRITIS SAMPLES

关节炎样本

• 批准号: 7368153
• 负责人: Susan Kovats
• 金额: $ 1.42万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7368153
• 关键词: ARTHRITIS; SAMPLES

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research is to study the effect of inflammatory stimuli (things that can activate a person's own immune system) on the response of a healthy person's immune cells to that person's own proteins. These studies are part of a research project about the autoimmune disease Rheumatoid Arthritis. Rheumatoid Arthritis is an autoimmune disease in which the immune system makes a destructive response toward the body's normal joint proteins, such as cartilage proteins. We currently are studying the ability of human blood cells to convert these joint proteins into forms recognizable by the immune system.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。所列机构为中心机构，不一定为研究者机构。这项研究的目的是研究炎症刺激（可以激活一个人自身免疫系统的东西）对健康人免疫细胞对该人自身蛋白质的反应的影响。这些研究是关于自身免疫性疾病风湿性关节炎的研究项目的一部分。风湿性关节炎是一种自身免疫性疾病，其中免疫系统对身体的正常关节蛋白（如软骨蛋白）产生破坏性反应。我们目前正在研究人类血细胞将这些关节蛋白转化为免疫系统可识别形式的能力。