NEURODEVELOPMENT EFFECTS OF ANTIEPILEPTIC DRUG STUDY (NEAD STUDY) (AMENDMENT #3R

抗癫痫药物研究（NEAD 研究）对神经发育的影响（修正案）

• 批准号: 7368198
• 负责人: LAURA A KALAYJIAN
• 金额: $ 1.09万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7368198
• 关键词: NEURODEVELOPMENT; EFFECTS; ANTIEPILEPTIC; DRUG; STUDY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary objective of this study is to differentiate the relative risks/benefit of four major AEDs in the treatment of women with epilepsy in terms of their children's neurobehavioral development after in utero exposure. The potential consequences of such cognitive and behavioral deficites in humans are severe in terms of both personal and societal costs. The results of the study will impact the clinical management of women receiving these medications, determine which of the major AEDs is safest in regard to neurobehavioral development and therefore improve the health of their children.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的主要目的是区分四种主要抗癫痫药治疗女性癫痫患者的相对风险/收益，以及子宫内接触后孩子的神经行为发育。就个人和社会成本而言，人类这种认知和行为缺陷的潜在后果是严重的。这项研究的结果将影响接受这些药物的妇女的临床管理，确定哪种主要的aed在神经行为发育方面是最安全的，从而改善她们孩子的健康。