ASSESSMENT OF PREVALENCE AND PERSISTENCE OF HUMAN PAPILLOMA- VIRUS (HPV) DNA IN

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。人类免疫缺陷病毒(HIV)感染是人类乳头瘤病毒(HPV)感染和女性生殖道HPV相关病变发展的重要危险因素。在对照临床试验的基础上已经确定：1)艾滋病毒感染妇女经历宫颈不典型增生(即鳞状上皮内瘤变)的可能性大约是艾滋病毒阴性妇女的五倍；以及2)在艾滋病毒感染妇女中，在宫颈阴道灌洗液(CVL)或阴道拭子中检测到HPV DNA的频率是从艾滋病毒阴性妇女获得的样本中检测到HPV DNA的两到五倍。这些发现表明，艾滋病毒感染和/或艾滋病毒相关的免疫抑制增加了妇女对HPV感染的易感性，或改变了先前存在的HPV感染的自然病史。目前尚不清楚治疗是否有效，抗逆转录病毒方案是否会影响HPV感染的持久性和宫颈异型增生的进展。据推测，恢复生殖道免疫监视将延缓持续HPV感染的建立，但这只能通过前瞻性地监测一组有记录的生殖器HPV感染多年的受试者来确定。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Human Immunodeficiency Virus (HIV) Infections is a significant risk factor for Human Papillomavirus (HPV) infection and the development of HPV-associated lesions in the female genital tract. It has been established on the basis of controlled clinical trials that: 1)HIV-infected women are approximately five times as likely to experience cervical dysplasia (i.e., squamous intraepithelial neoplasia) as HIV- negative women: and 2) in HIV-infected women, HPV DNA can be detected in cervicovaginal lavage fluid (CVL) or on vaginal cervical swabs two to five times as frequently as in specimens obtained from HIV- negative women. These findings suggest that HIV infection and/or HIV-related immunosuppression increase a women's susceptibility to HPV infection or alter the natural history of preexisting HPV infection. It is not known whether treatment will potent antiretroviral regimens could affect the persistence of HPV infection and progression of cervical dysplasia. Presumably, restoration of restoration of immune surveillance in the genital tract would retard the establishment of persistent HPV infection, but this can only be determined by prospectively monitoring a group of subjects with documented genital HPV infection over a period of years.