PERINATAL CORE PROTOCOL (PACTG P1025) (HIV)

围产期核心方案 (PACTG P1025) (HIV)

• 批准号: 7603908
• 负责人: ALICE STEK
• 金额: $ 14.44万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603908
• 关键词: Adherence; Computer Retrieval of Information on Scientific Projects Database; Counseling; Data; Development; Effectiveness; Funding; Grant; Guidelines; HIV-1; Infant; Institution; Intervention; Medical; Perinatal; Pregnancy; Pregnant Women; Protocols documentation; Rate; Research; Research Personnel; Resources; Risk; Risk Factors; Safety; Source; Testing; United States; United States National Institutes of Health; United States Public Health Service; Vertical Disease Transmission; Woman; Women' s Health; antiretroviral therapy

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To date, approximately 500-600 cases of vertical transmission of human immunodeficiency virus type 1 (HIV) occur annually in the United States. The dramatic reduction in vertical transmission rates in the United States is related to several factors, including: increased provision and acceptance of voluntary counseling and HIV testing of pregnant women, improvements in the medical management of HIV- infected pregnant women, and the development and increased acceptance of interventions to decrease the risk of mother-to-child transmission of HIV. Specific U.S public Health Service guidelines recommend antiretroviral therapy (ART) during pregnancy appropriate to maximize health of the women. However, data regarding the effectiveness and safety of and adherence to ART during pregnancy are limited. In addition, important questions remain unanswered regarding risk factors for vertical transmission and why interventions fail. and the safety of interventions for women and their infants.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 迄今为止，美国每年大约发生 500-600 例人类免疫缺陷病毒 1 型 (HIV) 垂直传播病例。 美国垂直传播率的大幅下降与多种因素有关，包括：增加对孕妇的自愿咨询和艾滋病毒检测的提供和接受程度、改善感染艾滋病毒孕妇的医疗管理、制定并提高接受旨在降低艾滋病毒母婴传播风险的干预措施。 具体的美国公共卫生服务指南建议在怀孕期间进行适当的抗逆转录病毒治疗（ART），以最大限度地提高女性的健康。 然而，有关妊娠期间 ART 的有效性、安全性和依从性的数据有限。 此外，关于垂直传播的危险因素以及干预措施为何失败的重要问题仍未得到解答。 以及妇女及其婴儿干预措施的安全性。