KIDNEY/PANCREAS TRANSPLANTATION FOR EXTENDED CRITERIA PATIENTS

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。传统上，全器官胰腺移植仅被考虑用于1型糖尿病患者，通常是那些患有肾衰竭的糖尿病并发症的患者，因此这些患者在之前的活体或尸体供体肾移植（PAK）后接受尸体肾-胰腺联合移植（KPTx）或胰腺移植。将对表现出联合（不足/抵抗）糖尿病表型特征的2型糖尿病患者进行胰腺移植，并研究（1）移植前胰岛素分泌状态和（2）胰岛素敏感性参数。该项目的具体目标是确定联合移植成功治疗患者的代谢特征，即胰岛素需求降至零。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Whole organ pancreas transplantation has traditionally been considered only for type 1 diabetics, usually those with the diabetic complication of renal failure, so that these patients received combined cadaveric kidney-pancreas transplants (KPTx) or a pancreas transplant after a previous living or cadaveric donor kidney transplant (PAK). Patients with type 2 diabetics displaying characteristics of the combined (insufficient/resistant) diabetic phenotype will be offered pancreas transplantation and studied with regard to (1) their pretransplant insulin secretory state and (2) parmeters of insulin sensitivty. The specific aim of this project is to establish metabolic characteristics of patients successfully treated with combined transplantation as defined by a decline of insulin requirements to zero.