KIDNEY/PANCREAS TRANSPLANTATION FOR EXTENDED CRITERIA PATIENTS

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。传统上，全器官胰腺移植仅被考虑用于1型糖尿病患者，通常是那些合并肾功能衰竭的糖尿病患者，因此这些患者在以前的活体或身体供体肾移植(PAK)后接受身体肾-胰腺联合移植(KPTx)或胰腺移植(PAK)。表现出混合(不足/抵抗)糖尿病表型特征的2型糖尿病患者将接受胰腺移植，并就(1)他们移植前的胰岛素分泌状态和(2)胰岛素敏感性参数进行研究。该项目的具体目标是建立成功接受联合移植治疗的患者的代谢特征，其定义是将胰岛素需求降至零。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Whole organ pancreas transplantation has traditionally been considered only for type 1 diabetics, usually those with the diabetic complication of renal failure, so that these patients received combined cadaveric kidney-pancreas transplants (KPTx) or a pancreas transplant after a previous living or cadaveric donor kidney transplant (PAK). Patients with type 2 diabetics displaying characteristics of the combined (insufficient/resistant) diabetic phenotype will be offered pancreas transplantation and studied with regard to (1) their pretransplant insulin secretory state and (2) parmeters of insulin sensitivty. The specific aim of this project is to establish metabolic characteristics of patients successfully treated with combined transplantation as defined by a decline of insulin requirements to zero.