NASAL HIGH-FREQUENCY VENTILATION FOR PREMATURE INFANTS

早产儿经鼻高频通气

• 批准号: 7377089
• 负责人: Tarah Trinity Colaizy
• 金额: $ 0.08万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-01 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7377089
• 关键词: NASAL; FREQUENCY; VENTILATION; PREMATURE; INFANTS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Prolonged mechanical ventilation is frequently needed to treat respiratory insufficiency and apnea in very low birth weight (VLBW, <1500 g) preterm infants. Endotracheal intubation and mechanical ventilation carry many risks including potentially fatal air leaks and ventilator-associated pneumonias. Less invasive methods of respiratory support are needed to minimize these risks while supporting the convalescing preterm infant. This protocol will test the effectiveness of nasal high-frequency ventilation (NHFV) in stable neonates with mild respiratory acidosis who are dependent on nasal continuous positive airway pressure for respiratory support (CPAP). Nasal high-frequency ventilation may be effective in decreasing rates of reintubation for apnea or respiratory insufficiency in VLBW infants. Enrollment will include 60 stable VLBW infants who are currently being treated with nasal CPAP and who have mild respiratory acidosis. Twenty patients will be assigned to each ventilator under investigation. Nasal high frequency ventilation will be applied at the same mean airway pressure as the patients' previous CPAP support. The amplitude of the nasal high frequency ventilation will be adjusted to achieve adequate shaking of the chest wall. Blood gas measurements, continuous transcutaneous PCO2 monitoring, continuous pulse oximetry, and chest x-rays will be used to assess safety and efficacy. Study power has been calculated to detect a difference (drop or rise) in PCO2 of 8 torr, a clinically relevant diffe

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在极低出生体重（VLBW, <1500 g）早产儿中，经常需要延长机械通气来治疗呼吸功能不全和呼吸暂停。气管插管和机械通气有许多风险，包括可能致命的空气泄漏和呼吸机相关肺炎。需要侵入性较小的呼吸支持方法，以尽量减少这些风险，同时支持康复的早产儿。本方案将测试鼻高频通气（NHFV）对依赖鼻持续气道正压呼吸支持（CPAP）的轻度呼吸性酸中毒稳定新生儿的有效性。鼻高频通气可有效降低VLBW婴儿呼吸暂停或呼吸功能不全的再插管率。纳入的患者包括60名稳定的VLBW婴儿，他们目前正在接受鼻腔CPAP治疗，并患有轻度呼吸性酸中毒。每个呼吸机将分配20名患者。在与患者既往CPAP支持相同的平均气道压力下应用鼻腔高频通气。调整鼻高频通气的幅度，使胸壁得到充分的震动。血气测量、连续经皮二氧化碳分压监测、连续脉搏血氧仪和胸部x光将用于评估安全性和有效性。研究功率已被计算，以检测8 torr的PCO2差异（下降或上升），这是一个临床相关的差异