NICHD Cooperative Multicenter Neonatal Research Network

项目摘要 爱荷华大学提交续签申请，要求继续参加NICHD 新生儿研究网络(RFA-HD-23-002)。我们寻求继续支持北大西洋公约组织的使命。 为了改善新生儿的医疗保健和结局，寻求解决方案以提高存活率 早产儿和危重新生儿的神经发育障碍或慢性病。我们 有几个优势将推动NRN的协作工作。 1.我们的NICU在照顾怀孕22周和23周时出生的危重婴儿方面处于世界领先地位。 爱荷华大学的这些人的存活率是美国最高的，而且 这些幸存者中的大多数都没有神经发育障碍。我们带来专业知识为您提供信息 研究设计以及可参与NRN的相对较大的危险人口 学习。我们超低出生体重儿的死亡率在NRN中一直是最低的。 2.我们在婴儿临床研究方面有着深厚的传统和文化。我们的临床研究 NICU的基础设施在成功参与多中心项目方面有数十年的记录 对重要的新生儿研究结果的研究和贡献。 3.我们的NICU是美国新兴新生儿专科领域的领先中心 血流动力学。我们的血流动力学小组开发了研究方法和超声心动图 的测量标准，在临床和临床应用方面都是全球专家。 生理学和介入研究。NRN可以利用这种专业知识来追求新的 研究设计。 4.作为一个以农村为主、经济以农业为基础的州唯一的学术医疗中心， 我们所代表的人口，在其他方面在NICHD网络中没有得到很好的代表。我们的合作伙伴 位于南卡罗来纳州苏福尔斯的Sanford Health网站增加了一名原住民，进一步加强了这种多样性 美国人口与我们农村人口的总和。如果网络研究的结果将是 推广到全国的患者，应该代表国家的这一大片地区。 爱荷华大学网络中心代表着这个地区和人口。 5.在过去的7年里，我们对北大西洋公约组织的工作作出了重大贡献。我们一直在 尽管我们的人口相对较少，但在几项研究中注册人数最多的网站之一，我们有 在试验和后续观察研究中，婴儿的随访率都很高。

Project Summary The University of Iowa submits this renewal application for continued participation in the NICHD Neonatal Research Network (RFA-HD-23-002). We seek to continue to support the mission of the NRN to improve healthcare and outcomes for newborns, seeking solutions to increase survival without neurodevelopmental impairment or chronic illness for premature and critically ill newborn infants. We have several strengths that will advance the collaborative work of the NRN. 1. Our NICU is a world leader in the care of periviable infants, born at 22 and 23 weeks’ gestation. The survival rate of this population at the University of Iowa is the best in the United States, and the majority of these survivors are free of neurodevelopmental impairment. We bring expertise to inform research design as well as a relatively large periviable population available to participate in NRN studies. Our mortality for extremely low birth weight infants is perennially among the lowest in the NRN. 2. We have a strong tradition and culture of clinical research in infants. Our clinical research infrastructure in the NICU has a decades-long track record of successful participation in multicenter studies and contributions to important neonatal study findings. 3. Our NICU is the leading US center in the emerging neonatal subspecialty of neonatal hemodynamics. Our Hemodynamics group has developed the study methods and echocardiographic measurement standards for this modality and are global experts in its use both clinically and in physiologic and interventional research. That expertise can be harnessed in the NRN to pursue novel study designs. 4. As the only academic medical center in a largely rural state with an economy based in agriculture, we represent a population that is not otherwise well represented in the NICHD Network. Our partner site at Sanford Health in Sioux Falls, SD further enhances this diversity with the addition of a Native American population to our combined rural population. If the results of Network studies are to be generalized to patients throughout the country, this large area of the country should be represented. The University of Iowa Network center represents this region and population. 5. We have contributed significantly to the NRN’s work through the last 7 years. We have been among the highest enrolling sites in several studies despite our relatively low population, and we have had excellent follow-up rates for infants both in trials and in the Follow-up observational study.