INSULIN RESISTANCE: IT'S ROLE IN WEIGHT LOSS AND CARDIOVASCULAR RISK

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的中心焦点是胰岛素介导的葡萄糖处置抵抗和代偿性高胰岛素血症在胰岛素抵抗（IR）调节中的重要性及其在体重减轻和心血管风险中的作用。本研究的目的是确定肥胖个体胰岛素抵抗/高胰岛素血症与减肥能力之间的关系。此外，还将讨论高胰岛素血症对冠心病风险的影响。非糖尿病患者和糖尿病患者都将被研究。该方案包括一项研究的几个有效部分，旨在评估宏量营养素成分对下述方面的影响：1)减轻体重的能力；2)在患有IR的超重或肥胖个体中降低心血管风险。整个研究预计总受试者筛选：300-400人入组：第1组：肥胖非糖尿病患者：60人；第2组：肥胖糖尿病患者仅饮食：36人；第3组：肥胖糖尿病单药治疗：45人；第4组：超重非糖尿病患者：20人；第5组：肥胖东南亚女性：20人

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central focus of this study is on the importance of resistance to insulin-mediated glucose disposal and compensatory hyperinsulinemia in modulation of insulin resistance (IR) and its role in weight loss and cardiovascular risk. The purpose of this study is to determine the relationship between insulin resistance/hyperinsulinemia and ability to lose weight in obese individuals. In addition, the impact of hyperinsulinemia on risk for coronary heart disease will be addressed. Both non-diabetics and diabetics will be studied. This protocol includes several active arms of a study designed to evaluate the impact of macronutrient composition on: 1) ability to lose weight 2) reduction in cardiovascular risk, among overweight or obese individuals with IR. Total subjects expected for entire study Screening: 300-400 Enrollment: Arm 1: obese nondiabetic: 60 Arm 2: obese diabetic diet only: 36 Arm 3: obese diabetic monotherapy: 45 Arm 4: overweight nondiabetic: 20 Arm 5: obese Southeast Asian women: 20 Adipose tissue biopsy substudy: 30