INSULIN RESISTANCE: IT'S ROLE IN WEIGHT LOSS AND CARDIOVASCULAR RISK

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的中心焦点是胰岛素介导的葡萄糖处置抵抗和代偿性高胰岛素血症在胰岛素抵抗(IR)调节中的重要性及其在体重减轻和心血管风险中的作用。 本研究的目的是确定肥胖者的胰岛素抵抗/高胰岛素血症与减肥能力的关系。此外，还将讨论高胰岛素血症对冠心病风险的影响。非糖尿病患者和糖尿病患者都将被研究。 该方案包括一项研究的几个活跃分支，该研究旨在评估常量营养素成分对以下方面的影响：1)减肥能力；2)在超重或肥胖的IR患者中降低心血管风险。 整个研究的预期主题总数 放映：300-400 招生： 手臂1：肥胖的非糖尿病患者：60 手臂2：仅限肥胖糖尿病饮食：36 手臂3：肥胖糖尿病单一疗法：45例 手臂4：超重非糖尿病：20 手臂5：肥胖的东南亚女性：20 脂肪组织活检亚研究：30

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central focus of this study is on the importance of resistance to insulin-mediated glucose disposal and compensatory hyperinsulinemia in modulation of insulin resistance (IR) and its role in weight loss and cardiovascular risk. The purpose of this study is to determine the relationship between insulin resistance/hyperinsulinemia and ability to lose weight in obese individuals. In addition, the impact of hyperinsulinemia on risk for coronary heart disease will be addressed. Both non-diabetics and diabetics will be studied. This protocol includes several active arms of a study designed to evaluate the impact of macronutrient composition on: 1) ability to lose weight 2) reduction in cardiovascular risk, among overweight or obese individuals with IR. Total subjects expected for entire study Screening: 300-400 Enrollment: Arm 1: obese nondiabetic: 60 Arm 2: obese diabetic diet only: 36 Arm 3: obese diabetic monotherapy: 45 Arm 4: overweight nondiabetic: 20 Arm 5: obese Southeast Asian women: 20 Adipose tissue biopsy substudy: 30