IL-1beta-induced changes in intracellular calcium dynamics and TrpC3 expression: delineation of the signal transduction cascade

IL-1β 诱导的细胞内钙动力学和 TrpC3 表达的变化：信号转导级联的描述

• 批准号: BB/E011772/1
• 负责人: Rachel Tribe
• 金额: $ 43.49万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FE011772%2F1
• 关键词: IL; 1beta; induced; changes; intracellular

Inflammation is a key biological progress that impacts on all aspects of life. It is implicated in fertilisation, embryo development, timing of birth, protection of the living organisms from infection, brain function and ageing. Inappropriate activation of inflammatory processes underlies the development of asthma, arthritis, cardiovascular disease, premature labour and tumour formation. It is essential for scientists, therefore, to fully understand how inflammation influences organisms at the tissue and cellular level. Our project looks how inflammation is involved in priming the pregnant uterus for labour. We seek to understand how an inflammatory agent arriving at the surface of a uterine muscle cell can cause changes in deep within cells in order to switich on specific genes and thereby ultimately make the uterus muscle more capable of contracting powerfully during labour. Knowledge of this process will not only help us understand labour but give new insights into how similar muscles found in blood vessels, airways, gut and the bladder respond to inflammation. This will hopefully inform other researchers attempting to find ways to combat a wide range of diseases and promote human health.

炎症是影响生活方方面面的关键生物学过程。它与受精、胚胎发育、出生时间、保护生物体免受感染、大脑功能和衰老有关。炎症过程的不适当激活是哮喘、关节炎、心血管疾病、早产和肿瘤形成的基础。因此，科学家必须充分了解炎症如何在组织和细胞水平上影响生物体。我们的项目研究炎症是如何参与孕妇子宫准备分娩的。我们试图了解到达子宫肌肉细胞表面的炎症因子如何引起细胞深处的变化，从而开启特定的基因，从而最终使子宫肌肉在分娩过程中更有能力有力地收缩。对这一过程的了解不仅有助于我们理解分娩过程，而且对血管、气道、肠道和膀胱中的类似肌肉如何对炎症做出反应提供了新的见解。这将有望为其他试图找到对抗各种疾病和促进人类健康的方法的研究人员提供信息。

项目成果

Nuclear factor of activated T-cell isoform expression and regulation in human myometrium.

• DOI: 10.1186/s12958-015-0086-0
• 发表时间: 2015-08-04
• 期刊: Reproductive biology and endocrinology : RB&E
• 作者: Chin-Smith EC;Willey FR;Slater DM;Taggart MJ;Tribe RM
• 通讯作者: Tribe RM

Stretch-induced regulation of labour associated genes in human myometrial cells - understanding the role of intracellular calcium

人类子宫肌细胞中分娩相关基因的拉伸诱导调节——了解细胞内钙的作用

• 发表时间: 2010
• 作者: Willey FR