Understanding phenotype and mechanisms of spontaneous preterm birth in sub-Saharan Africa (PRECISE-SPTB)

了解撒哈拉以南非洲地区自发性早产的表型和机制 (PRECISE-SPTB)

• 批准号: MR/T03890X/1
• 负责人: Rachel Tribe
• 金额: $ 151.27万
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=MR%2FT03890X%2F1
• 关键词: Understanding; phenotype; mechanisms; spontaneous; preterm

Preterm birth, birth before 37 weeks of pregnancy, is a major cause of infant death and illness in sub-Saharan Africa. Over 80% of preterm births globally have been estimated to occur in sub-Saharan African (sSA) and Asian countries, the majority being due to women going into preterm labour spontaneously or their membranes (waters) rupture early (classified together as spontaneous preterm birth, SPTB). Despite knowledge of the global impact of SPTB, most of the research into this often devastating pregnancy outcome has focussed on pregnant women in high income countries such as the UK and USA. Much less in known about SPTB in women from low income countries. However, the underlying biological causes of SPTB are complex and heavily influenced by environment, nutrition, infection and other risk factors that pregnant women are exposed to. Region specific research is essential if we are to improve maternal and newborn healthcare in countries where the burden of preterm birth is highest. Addressing this need, we plan to study to clinical and social risk factors (from 5000 women recruited to the PRECISE Network pregnancy cohort, https://precisenetwork.org/) combined with biological markers of SPTB in the female reproductive tract, blood and placental tissue in women from Kenya, The Gambia and Mozambique. We will integrate these data to enhance our biological understanding of SPTB as well as identifying novel biomarkers relevant to sub-Saharan African populations to predict risk of SPTB.We will also create sustainable teams of SPTB researchers by training five new African scientists and supporting their supervisor as research leaders. We will, with colleagues in The Gambia, establish a bioinformatics training programme and a laboratory science network for our researchers in Sub Saharan Africa and the UK. We anticipate that this work will impact future strategies for clinical risk management, prevention and treatment that specifically addresses the needs of women in sub-Saharan Africa, as well as having potential relevance to SPTB globally.

在撒哈拉以南非洲，早产是导致婴儿死亡和疾病的主要原因。据估计，全球80%以上的早产发生在撒哈拉以南非洲(SSA)和亚洲国家，其中大部分是由于妇女自发早产或其胎膜(羊水)过早破裂(一起归类为自发早产)。尽管知道SPTB对全球的影响，但对这种往往具有破坏性的妊娠结局的大多数研究都集中在英国和美国等高收入国家的孕妇身上。人们对低收入国家妇女感染肺结核的了解要少得多。然而，SPTB的潜在生物学原因是复杂的，并受到环境、营养、感染和孕妇暴露在其中的其他危险因素的严重影响。如果我们要在早产负担最重的国家改善孕产妇和新生儿保健，特定地区的研究是必不可少的。针对这一需求，我们计划研究临床和社会风险因素(从5,000名招募到精密网络怀孕队列的妇女中)，在肯尼亚、冈比亚和莫桑比克的妇女中，将https://precisenetwork.org/)与女性生殖道、血液和胎盘组织中的肺结核生物标志物相结合。我们将整合这些数据，以增强我们对SPTB的生物学理解，并识别与撒哈拉以南非洲人口相关的新生物标记物，以预测SPTB的风险。我们还将通过培训五名新的非洲科学家并支持他们的主管担任研究领导者，创建可持续的SPTB研究团队。我们将与冈比亚的同事一起，为我们在撒哈拉以南非洲和英国的研究人员建立生物信息学培训计划和实验室科学网络。我们预计，这项工作将影响未来的临床风险管理、预防和治疗战略，这些战略专门解决撒哈拉以南非洲妇女的需求，并可能与全球的SPTB相关。

项目成果

Microbiota dynamics, metabolic and immune interactions in the cervicovaginal environment and their role in spontaneous preterm birth.

• DOI: 10.3389/fimmu.2023.1306473
• 发表时间: 2023
• 期刊: Frontiers in immunology
• 影响因子: 7.3
• 作者: Onyango S;Mi JD;Koech A;Okiro P;Temmerman M;von Dadelszen P;Tribe RM;Omuse G;PRECISE Network
• 通讯作者: PRECISE Network

Predicting Preterm Birth Using Cell-Free Ribonucleic Acid

• DOI: 10.1016/j.clp.2024.02.008
• 发表时间: 2024-05-03
• 期刊: CLINICS IN PERINATOLOGY
• 影响因子: 2.1
• 作者: Cowan，Alison D.;Rasmussen，Morten;Tribe，Rachel M.
• 通讯作者: Tribe，Rachel M.