CONT PSTV AIRWAY PRESS&INSLN SENSITIZATION W/ROSIG ON ERECTILE DYSFNCTN W/APNEA

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。这项研究的目的是了解阻塞性睡眠呼吸暂停是如何影响勃起功能和激素水平的。我们正在研究胰岛素抵抗，这是2型糖尿病的潜在原因。当身体无法对自身产生的胰岛素做出适当反应时，就会发生胰岛素抵抗。这项研究是为了检查患有阻塞性睡眠呼吸暂停的人是否有胰岛素抵抗，这可能会使他们的性功能恶化。我们将对所有患者进行持续气道正压通气治疗，这是睡眠呼吸暂停患者的标准治疗方法。此外，一半的患者将接受一种最初用于治疗2型糖尿病的药物，这种药物可以帮助身体对胰岛素更敏感。我们希望它也能改善勃起功能障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to see how obstructive sleep apnea affects erectile function and hormone levels. We are looking at insulin resistance, an underlying cause of type 2 diabetes. Insulin resistance occurs when the body fails to respond properly to the insulin it already produces. This study is examining whether people who have obstructive sleep apnea have insulin resistance that may be worsening their sexual function. We will be treating all patients with continuous positive airway pressure, the standard of care for patients with sleep apnea. In addition, half the patients will receive a drug used initially in the treatment of Type 2 diabetes that helps the body become more sensitive to insulin. We hope that it will improve erectile dysfunction as well.