CONT PSTV AIRWAY PRESS&INSLN SENSITIZATION W/ROSIG ON ERECTILE DYSFNCTN W/APNEA

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这项研究的目的是了解阻塞性睡眠呼吸暂停对勃起功能和激素水平的影响。我们正在研究胰岛素抵抗，这是2型糖尿病的一个潜在原因。当身体不能对已经产生的胰岛素做出适当的反应时，就会发生胰岛素抵抗。这项研究正在调查患有阻塞性睡眠呼吸暂停的人是否存在胰岛素抵抗，这可能会恶化他们的性功能。我们将治疗所有持续气道正压的患者，这是睡眠呼吸暂停患者的标准护理。此外，一半的患者将接受一种最初用于治疗2型糖尿病的药物，该药物有助于身体对胰岛素变得更敏感。我们希望它也能改善勃起功能障碍。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this study is to see how obstructive sleep apnea affects erectile function and hormone levels. We are looking at insulin resistance, an underlying cause of type 2 diabetes. Insulin resistance occurs when the body fails to respond properly to the insulin it already produces. This study is examining whether people who have obstructive sleep apnea have insulin resistance that may be worsening their sexual function. We will be treating all patients with continuous positive airway pressure, the standard of care for patients with sleep apnea. In addition, half the patients will receive a drug used initially in the treatment of Type 2 diabetes that helps the body become more sensitive to insulin. We hope that it will improve erectile dysfunction as well.