EXERCISE REHABILITATION FOR THE OLDER CANCER PATIENT

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。当患有结肠癌的老年人接受化疗时，他们往往会感到非常疲惫和虚弱。自我报告的高度疲劳与功能表现和生活质量的降低有关。功能丧失最终会导致身体、心理和情感上的痛苦，给患者及其家人带来潜在的破坏性经济和社会后果。目前尚不清楚患者能否完全从这种损失中恢复过来。我们正在研究运动如何帮助患有结肠癌的老年人在接受化疗时感觉不那么疲倦，肌肉无力也更少。举重增强了50岁左右癌症患者的胳膊和腿，但运动对保护身体功能和减少癌症老年人疲劳的效果尚不清楚。40名年龄在65岁或以上的被诊断患有结肠癌的女性和男性将从丹佛地区的肿瘤学诊所招募。参与者将被筛选出锻炼的安全性，然后随机分配到锻炼组或非锻炼对照组。干预将超过6个月，在第一个化疗周期之前开始。运动组的参与者将接受个性化的指导，进行力量训练。将鼓励参与者每周锻炼3次，在锻炼研究机构进行家庭锻炼和监督锻炼相结合。随机分为非运动控制组的参与者将在研究措施完成后接受为期6个月的监督运动计划。所有参与者将在干预开始时、3个月和6个月完成功能表现测试和问卷调查，以评估疲劳和生活质量。我们主要感兴趣的是测量这两组人身体功能和自我报告的疲劳感的变化。我们还将测量血液中的一些激素水平，这可能有助于我们更好地了解运动和化疗是如何影响疲劳和身体功能的。这项研究是由国家癌症研究所和国家卫生研究院资助的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. When older people with colon cancer undergo chemotherapy, they tend to feel very tired and to become weak. High levels of self-reported fatigue are associated with reductions in functional performance and quality of life. Functional losses ultimately result in physical, psychological and emotional distress with potentially devastating economic and social consequences for patients and their families. Whether patients can fully recover from such losses remains unclear. We are studying how exercise may help older people with colon cancer feel less fatigue and have less muscle weakness as they go through chemotherapy. Lifting weights strengthened the arms and legs of women and men who had cancer and were about 50 years old, but the effects of exercise to protect physical function and reduce fatigue in older persons with cancer are not known. Forty women and men aged 65 years or older who have been diagnosed with colon cancer will be recruited from oncology practices in the Denver area. The participants will be screened for safety to exercise, and then randomly assigned to an exercise group or a non-exercising control group. The intervention will be over 6 months, beginning just before the first cycle of chemotherapy. Participants in the exercise group will receive individualized instructions for performing strength-building exercises. The participants will be encouraged to exercise 3 times per week using a combination of home-based and supervised exercises in an exercise research facility. Participants randomized to the non-exercise control group will be offered a 6-month supervised exercise program after the completion of study measures. All participants will complete a functional performance test and questionnaires to assess fatigue and quality of life at the beginning of the intervention, at 3 months and 6 months. We are primarily interested in measuring changes in physical function and self-reported fatigue in the two groups. We will also measure some hormone levels in the blood that may help us to better understand how exercise and chemotherapy affects fatigue and physical function. This study is funded by the National Cancer Institute and the National Institutes of Health.