EXERCISE REHABILITATION FOR THE OLDER CANCER PATIENT

老年癌症患者的运动康复

• 批准号: 7604402
• 负责人: DAN BARRY
• 金额: $ 7.78万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604402
• 关键词: Affect; Area; Blood; Cancer Patient; Colon Carcinoma; Computer Retrieval of Information on Scientific Projects Database; Control Groups; Diagnosis; Economics; Elderly; Exercise; Family; Fatigue; Funding; Grant; Home environment; Hormones; Institution; Instruction; Intervention; Leg; Malignant Neoplasms; Measures; Muscle Weakness; National Cancer Institute; Participant; Patient Self-Report; Patients; Performance; Physical Function; Quality of life; Questionnaires; Randomized; Recruitment Activity; Rehabilitation therapy; Research; Research Personnel; Resources; Safety; Source; Time; United States National Institutes of Health; Upper arm; Week; Weight Lifting; Woman; aged; base; chemotherapy; emotional distress; functional loss; interest; men; oncology; performance tests; programs; psychologic; research facility; social

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. When older people with colon cancer undergo chemotherapy, they tend to feel very tired and to become weak. High levels of self-reported fatigue are associated with reductions in functional performance and quality of life. Functional losses ultimately result in physical, psychological and emotional distress with potentially devastating economic and social consequences for patients and their families. Whether patients can fully recover from such losses remains unclear. We are studying how exercise may help older people with colon cancer feel less fatigue and have less muscle weakness as they go through chemotherapy. Lifting weights strengthened the arms and legs of women and men who had cancer and were about 50 years old, but the effects of exercise to protect physical function and reduce fatigue in older persons with cancer are not known. Forty women and men aged 65 years or older who have been diagnosed with colon cancer will be recruited from oncology practices in the Denver area. The participants will be screened for safety to exercise, and then randomly assigned to an exercise group or a non-exercising control group. The intervention will be over 6 months, beginning just before the first cycle of chemotherapy. Participants in the exercise group will receive individualized instructions for performing strength-building exercises. The participants will be encouraged to exercise 3 times per week using a combination of home-based and supervised exercises in an exercise research facility. Participants randomized to the non-exercise control group will be offered a 6-month supervised exercise program after the completion of study measures. All participants will complete a functional performance test and questionnaires to assess fatigue and quality of life at the beginning of the intervention, at 3 months and 6 months. We are primarily interested in measuring changes in physical function and self-reported fatigue in the two groups. We will also measure some hormone levels in the blood that may help us to better understand how exercise and chemotherapy affects fatigue and physical function. This study is funded by the National Cancer Institute and the National Institutes of Health.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 当患有结肠癌的老年人接受化疗时，他们往往会感到非常疲倦并变得虚弱。自我报告的高水平疲劳与功能表现和生活质量的降低有关。功能丧失最终会导致身体、心理和情感上的痛苦，对患者及其家人造成潜在的破坏性经济和社会后果。患者能否从这种损失中完全恢复尚不清楚。我们正在研究如何锻炼可以帮助患有结肠癌的老年人在化疗时减少疲劳和肌肉无力。举重增强了50岁左右的癌症患者的手臂和腿部，但运动对保护身体功能和减少癌症患者疲劳的影响尚不清楚。将从丹佛地区的肿瘤学实践中招募40名年龄在65岁或65岁以上的被诊断患有结肠癌的女性和男性。参与者将被筛选为安全运动，然后随机分配到一个运动组或一个非运动对照组。干预将超过6个月，在第一个化疗周期之前开始。运动组的参与者将接受个性化的指导，以进行力量训练。将鼓励参与者在运动研究设施中每周锻炼3次，结合家庭和监督锻炼。 随机分配至非运动对照组的受试者将在完成研究措施后接受为期6个月的监督运动计划。所有参与者将在干预开始时、3个月和6个月时完成功能性能测试和问卷调查，以评估疲劳和生活质量。我们主要感兴趣的是测量两组中身体功能和自我报告的疲劳的变化。我们还将测量血液中的一些激素水平，这可能有助于我们更好地了解运动和化疗如何影响疲劳和身体功能。这项研究由美国国家癌症研究所和美国国立卫生研究院资助。