GENES OF HYPERTENSION IN AFRICAN AMERICANS

非裔美国人的高血压基因

• 批准号: 7375056
• 负责人: Theodore Kotchen
• 金额: $ 43.63万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375056
• 关键词: GENES; HYPERTENSION; AFRICAN; AMERICANS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that we will be able to identify genes contributing to hypertension in African Americans by focusing on the physiological pathways that determine arterial pressure. We propose to extensively phenotype 500 hypertensive and 500 normotensive African American subjects to conduct a genetic association study, using a SNP genomic scan approach. Inclusion of phenotypes is based on their relevance to the pathophysiology of hypertension and prior evidence of "heritability". Candidate genes for SNP analysis will be based on QTLs previously identified by ourselves and others. A final goal of the project is to determine if distinct clusters of blood pressure-related phenotypes can be identified that will permit stratification of hypertensive individuals into distinct subgroups to facilitate the analysis of the genetic determinants of hypertension.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。我们假设，通过关注决定动脉压的生理途径，我们将能够识别导致非裔美国人高血压的基因。我们建议使用SNP基因组扫描方法，对500名高血压和500名正常的非裔美国受试者进行广泛的表型分析，以进行遗传关联研究。包括表型是基于它们与高血压病理生理的相关性和先前的“遗传性”证据。SNP分析的候选基因将基于我们自己和其他人之前确定的qtl。该项目的最终目标是确定是否可以确定血压相关表型的不同集群，从而将高血压个体分层为不同的亚组，以促进高血压遗传决定因素的分析。