FAMILIAL DETERMINANTS OF HYPERTENSION

高血压的家族决定因素

• 批准号: 7375055
• 负责人: Theodore Kotchen
• 金额: $ 47.23万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375055
• 关键词: FAMILIAL; DETERMINANTS; HYPERTENSION

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We hypothesize that we will be able to identify genes contributing to hypertension in African Americans by focusing on physiological pathways that determine arterial pressure. The design is a case-control study involving hypertensive and normotensive African Americans. This protocol involves a single outpatient visit during which the following are obtained: brief history, standardized blood pressure, anthropometric measurements; peripheral venous blood for a basic chemistry panel and DNA. Based on thie information, subjects satisfying inclusion criteria will be invited to participate in a related inpatient protocol, which involves more extensive phenotyping.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。我们假设，我们将能够确定基因有助于高血压在非洲裔美国人通过关注生理途径，决定动脉压。该研究设计为病例对照研究，涉及高血压和血压正常的非裔美国人。该方案涉及一次门诊访视，在此期间获得以下内容：病史、标准化血压、人体测量结果;外周静脉血用于基础化学检查和DNA。根据这些信息，将邀请符合入选标准的受试者参加相关住院方案，该方案涉及更广泛的表型分析。