FMRI EVALUATION OF PARKINSON'S DISEASE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。本项目将研究任务激活功能磁共振成像作为量化帕金森病(PD)治疗反应的生物标记物的有效性。其具体目的是：(1)确定任务激活功能磁共振成像在检测接受和不接受多巴胺能替代治疗的帕金森病患者脑激活模式变化方面的敏感性，(2)将任务激活功能磁共振成像对治疗反应的相对敏感性与已有的临床结果指标进行比较，以及(3)确定任务激活功能磁共振成像在健康老年人中的重测可靠性。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project will investigate the efficacy of task-activated fMRI as a biomarker for quantifying a therapeutic response in Parkinson's Disease (PD). The specific aims are to: (1) determine the sensitivity of task-activated fMRI for detecting changes in brain activation patterns occurring in PD patients on and off dopaminergic replacement therapy, (2) compare the relative sensitivity to therapeutic response of task-activated fMRI compared to established clinical outcome measures, and (3) determine the test-retest reliability of task-activated fMRI in healthy older adults.