FUNCTIONAL MRI OF COGNITIVE PROCESSES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。该项目的总体目标是开发健康成人认知功能的神经解剖学脑图，并将这些知识应用于认知功能障碍患者（多发性硬化症、阿尔茨海默病、中风）的研究。为了实现这一目标，我们将进行涉及五个认知领域的任务激活实验：(1)工作记忆，(2)外显和内隐长期记忆，(3)选择性、分裂和持续注意，(4)复杂运动过程，以及(5)概念推理。这项针对健康成人的研究将会产生关于认知活动中功能解剖关系的重要新信息。这些研究还将为实现我们广泛的长期目标提供必要的信息：开发一种全面的功能性脑成像方法来研究产生认知障碍的神经系统疾病。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of this project is to develop a neuroanatomic brain map of cognitive functions in healthy adults and apply this knowledge to the study of patients with cognitive dysfunction (multiple sclerosis, Alzheimer's disease, stroke). To achieve this goal, we will perform task activation experiments involving five cognitive domains: (1) working memory, (2) explicit and implicit long-term memory, (3) selective, divided, and sustained attention, (4) complex motor processes, and (5) conceptual reasoning. The proposed work on healthy adults should yield important new information regarding functional anatomic relationships during cognitive activity. These studies will also provide essential information needed to achieve our broad, long-term objective: to develop a comprehensive functional brain imaging approach to the study of neurological disorders that produce cognitive impairment.