FMRI OF THE PERSON IDENTITY NETWORK: AGING AND APOE

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。认识和识别一个熟悉的人的过程代表了日常社会互动的基本活动。目前的观点认为，一系列不同的、相互作用的认知操作构成了这一过程的基础，我们将其称为个人身份网络（PIN）。迄今为止，大多数关于介导PIN的神经系统的信息都来自神经学群体的研究。这一信息表明，对熟悉的面孔和名字的识别和识别似乎具有不同的操作特征，并且可能由与一般物体识别和识别明显不同的神经网络提供服务。本项目将应用事件相关功能MRI （ER-fMRI）技术来更好地了解PIN的神经基质。具体来说，我们提出了一系列功能磁共振成像实验来检测年轻健康成年人和健康老年人的PIN，这些老年人拥有或不拥有载脂蛋白ee4 （APOE e4）等位基因。这些研究的结果有望为几个关键问题提供新的见解，这些问题介导了PIN的检索和记忆病理的神经生物学基础，这些基础可能预示着与年龄相关的异常记忆功能。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The process of recognizing and identifying a familiar person represents a basis activity of daily social interaction. Current viewpoints suggest that a sequence of distinct and interactive cognitive operations underlie this process, whch we refer to as the Person Identity Network (PIN). To date, most of the information concerning the neural systems that mediate the PIN comes from studies with neurological populations. This information suggest that recognition and identification of familiar faces and names appear to have different operating characteristics, and may be subserved by a neural network that is distinct from that evident for general object recognition and identification. This project will apply event-related functional MRI (ER-fMRI) technology to better understand the neural substrates of the PIN. Specifically, we propose a series of fMRI experiments examing the PIN in young healthy adults and in healthy older adults who either possess or do not possess the apolipoprotein E e4 (APOE e4) allele. The results from these studies are expected to provide novel insights into several critical issues that mediate retrieval from the PIN and the neurobiological substrates of memory pathology that may presage abnormal age-related memory functioning.