FMRI OF THE PERSON IDENTITY NETWORK: AGING AND APOE

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。识别和辨认一个熟悉的人的过程代表着日常社会交往的一项基本活动。目前的观点认为，这一过程是一系列不同的和交互的认知操作，我们称之为个人身份网络(PIN)。到目前为止，大多数关于调节PIN的神经系统的信息都来自于对神经学人群的研究。这些信息表明，对熟悉的面孔和名字的识别和识别似乎具有不同的操作特征，并且可能由不同于一般物体识别和识别的明显的神经网络来辅助。该项目将应用事件相关功能磁共振(ER-fMRI)技术，以更好地了解PIN的神经基础。具体地说，我们提出了一系列的功能磁共振实验，在年轻的健康成年人和拥有或不拥有载脂蛋白E e4(ApoE E4)等位基因的健康老年人中检测PIN。这些研究的结果有望为几个关键问题提供新的见解，这些问题调解从PIN和可能预示年龄相关记忆功能异常的记忆病理的神经生物学底物进行检索。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The process of recognizing and identifying a familiar person represents a basis activity of daily social interaction. Current viewpoints suggest that a sequence of distinct and interactive cognitive operations underlie this process, whch we refer to as the Person Identity Network (PIN). To date, most of the information concerning the neural systems that mediate the PIN comes from studies with neurological populations. This information suggest that recognition and identification of familiar faces and names appear to have different operating characteristics, and may be subserved by a neural network that is distinct from that evident for general object recognition and identification. This project will apply event-related functional MRI (ER-fMRI) technology to better understand the neural substrates of the PIN. Specifically, we propose a series of fMRI experiments examing the PIN in young healthy adults and in healthy older adults who either possess or do not possess the apolipoprotein E e4 (APOE e4) allele. The results from these studies are expected to provide novel insights into several critical issues that mediate retrieval from the PIN and the neurobiological substrates of memory pathology that may presage abnormal age-related memory functioning.