PACTG P1045 VERSION 10

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。这是一项横断面研究，旨在（1）全面评估垂直HIV感染和未感染HIV的儿童和青少年的糖代谢、血脂水平、身体成分、脂肪沉积和分布以及骨密度异常的患病率，（2）评估PI暴露是否与HIV感染儿童和青少年的代谢和形态异常相关，和（3）根据坦纳分期比较该人群中异常的患病率。这些数据对于设计干预试验和旨在研究病理生理机制的研究至关重要。共入组450例受试者。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a cross-sectional study designed to (1) comprehensively evaluate the prevalence of abnormalities in glucose metabolism, serum lipid levels, body composition, fat deposition and distribution, and bone density in vertically HIV-infected and HIV-uninfected children and youth, (2) evaluate whether exposure to PIs is correlated with the metabolic and morphologic abnormalities among HIV-infected children and youth, and (3) compare the prevalence of abnormalities in this population according to Tanner Stage. These data are critical for designing intervention trials and studies designed to study pathophysiologic mechanisms. A total of 450 subjects will be enrolled.