PACTG P1045 VERSION 10

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。这是一项横断面研究，旨在(1)全面评估垂直感染HIV和未感染HIV的儿童和青少年中糖代谢、血脂水平、身体成分、脂肪沉积和分布以及骨密度异常的患病率，(2)评估暴露于PI是否与HIV感染的儿童和青少年的代谢和形态异常相关，以及(3)根据Tanner分期比较这一人群中异常的患病率。这些数据对于设计干预试验和研究病理生理机制至关重要。报名人数为450人。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This is a cross-sectional study designed to (1) comprehensively evaluate the prevalence of abnormalities in glucose metabolism, serum lipid levels, body composition, fat deposition and distribution, and bone density in vertically HIV-infected and HIV-uninfected children and youth, (2) evaluate whether exposure to PIs is correlated with the metabolic and morphologic abnormalities among HIV-infected children and youth, and (3) compare the prevalence of abnormalities in this population according to Tanner Stage. These data are critical for designing intervention trials and studies designed to study pathophysiologic mechanisms. A total of 450 subjects will be enrolled.