PACTG P1045: MORPHOLOGIC & METABOLIC ABNORMALITIES IN VERTICALLY HIV-INFECTED

PACTG P1045：形态学

• 批准号: 7374363
• 负责人: Elizabeth Jane McFarland
• 金额: $ 0.99万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-24 至 2007-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374363
• 关键词: children; experimental designs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cross-sectional study designed to evaluate the prevalence of morphologic and metabolic abnormalities in vertically HIV-infected children and youth and uninfected children and youth. This is a cross-sectional study designed to comprehensively evaluate the prevalence of abnormalities in glucose metabolism, serum lipid levels, body composition, fat deposition and distribution, and bone density in vertically HIV-infected and HIV-uninfected children and youth, evaluate whether exposure to PIs is correlated with the metabolic and morphologic abnormalities among HIV-infected children and youth, and compare the prevalence of abnormalities in this population according to Tanner Stage. HIV infected receiving antiretroviral treatment and untreated, uninfected subjects, aged 7-25 years will be enrolled. A total of 450 subjects will be enrolled, stratified by Tanner Stage, HIV infection status, and protease inhibitor therapy. Screening clinical and laboratory evaluations will be completed at one visit and on-study clinical and laboratory evaluations may be completed within 30 days of Entry. These data are critical for designing intervention trials and studies designed to study pathophysiologic mechanisms.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。横断面研究旨在评估纵向HIV感染儿童和青少年与未感染儿童和青少年的形态学和代谢异常的患病率。这是一项横断面研究，旨在全面评估垂直HIV感染和未感染HIV的儿童和青少年的糖代谢、血脂水平、身体成分、脂肪沉积和分布以及骨密度异常的患病率，评估暴露于PI是否与HIV感染儿童和青少年的代谢和形态异常相关，并根据坦纳分期比较该人群的异常患病率。将入组接受抗逆转录病毒治疗的HIV感染者和未经治疗的未感染受试者，年龄为7-25岁。共入组450例受试者，按坦纳分期、HIV感染状态和蛋白酶抑制剂治疗分层。筛选临床和实验室评价将在一次访视时完成，研究期间临床和实验室评价可在入组后30天内完成。这些数据对于设计干预试验和旨在研究病理生理机制的研究至关重要。