PACTG P1045: MORPHOLOGIC & METABOLIC ABNORMALITIES IN VERTICALLY HIV-INFECTED

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cross-sectional study designed to evaluate the prevalence of morphologic and metabolic abnormalities in vertically HIV-infected children and youth and uninfected children and youth. This is a cross-sectional study designed to comprehensively evaluate the prevalence of abnormalities in glucose metabolism, serum lipid levels, body composition, fat deposition and distribution, and bone density in vertically HIV-infected and HIV-uninfected children and youth, evaluate whether exposure to PIs is correlated with the metabolic and morphologic abnormalities among HIV-infected children and youth, and compare the prevalence of abnormalities in this population according to Tanner Stage. HIV infected receiving antiretroviral treatment and untreated, uninfected subjects, aged 7-25 years will be enrolled. A total of 450 subjects will be enrolled, stratified by Tanner Stage, HIV infection status, and protease inhibitor therapy. Screening clinical and laboratory evaluations will be completed at one visit and on-study clinical and laboratory evaluations may be completed within 30 days of Entry. These data are critical for designing intervention trials and studies designed to study pathophysiologic mechanisms.