Elucidating the critical role of metabolic stress in central and peripheral mechanisms of adaptation to endurance exercise training

阐明代谢应激在适应耐力运动训练的中枢和外周机制中的关键作用

• 批准号: RGPIN-2022-03029
• 负责人: Murias, Juan
• 金额: $ 2.84万
• 依托单位: University of Calgary
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2022
• 资助国家: 加拿大
• 起止时间: 2022-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=757903
• 关键词: Elucidating; critical; role; metabolic; stress

Objectives of proposed research program Endurance exercise training aims to improve cardiovascular function by changing how central (i.e., the heart) and peripheral (i.e., the small vessels within the muscles) mechanisms control the transport and distribution of oxygen (O2) to the muscles that need it. However, in some people, endurance training fails to achieve this goal. Although some believe that genetic factors determine whether someone will benefit from endurance training, work from my laboratory shows that every individual can improve their cardiovascular function if exercise training is of appropriate intensity. Thus, I have proposed that by using a personalized exercise program that precisely considers the stress that the exercise causes to the body will result in everyone benefiting from endurance training. The objective of my research program is to understand the mechanisms that control central and peripheral adaptations to endurance exercise training under experimental conditions where the level of stress is accurately quantified. I will explore the controversial hypotheses that: i) the so-called "non-responders" to exercise do not exist when the appropriate exercise intensity is applied; and ii) central and peripheral adaptations will contribute differently depending on the exercise intensity assigned to the intervention. Summary of scientific approach I will perform a 10-week endurance training program where participants will be assigned to 4 training groups: 1) Moderate intensity continuous exercise (MOD; minimal physical stress); 2) Heavy intensity continuous exercise 1 (HVY1; small physical stress); 3) Heavy intensity continuous exercise training 2 (HVY2; large physical stress); 4) High intensity interval training (HIIT; large physical stress). Application of this model will ensure that the stress of exercise will be different between but identical within groups. Using different measures of central and peripheral cardiovascular function during and after training, I will determine the mechanisms responsible for the adaptations in each group. My laboratory is uniquely equipped to execute this research plan using non-invasive or minimally invasive approaches. Novelty and expected significance Current approaches are inadequate to prescribe the appropriate stress of exercise to participants. This is a critical limitation that questions the validity of current methods to evaluate the mechanisms that control adaptations to endurance training. Applying a novel exercise model that precisely controls the stress of the exercise, my research program will: 1) demonstrate that cardiovascular adaptations to endurance training are determined by the stress of the intervention; 2) challenge the concept of "non-responders" to exercise. This will make a critical contribution providing scientists and practitioners with precise information to perform their work more effectively.

拟议研究计划的目标耐力运动训练旨在通过改变如何中心（即，心脏）和外周（即，肌肉内的小血管）机制控制氧气（O2）的运输和分配到需要它的肌肉。2然而，在一些人中，耐力训练无法实现这一目标。虽然有些人认为遗传因素决定了一个人是否会从耐力训练中受益，但我实验室的工作表明，如果运动训练强度适当，每个人都可以改善心血管功能。因此，我建议，通过使用个性化的锻炼计划，精确地考虑锻炼对身体造成的压力，将使每个人都从耐力训练中受益。我的研究项目的目的是了解控制中枢和外周适应耐力运动训练的实验条件下，压力水平是准确量化的机制。我将探讨有争议的假设，即：i）所谓的“无反应者”运动不存在时，适当的运动强度应用;和ii）中央和外周适应将有助于不同的运动强度分配给干预。科学方法总结我将进行为期10周的耐力训练计划，参与者将被分配到4个训练组：1）中等强度的持续运动（MOD;最小的身体压力）; 2）高强度持续运动1（HVY 1;小体力负荷）; 3）大强度持续运动训练2（HVY 2;大的身体应激）; 4）高强度间歇训练（HIIT;大的身体应激）。应用这个模型将确保运动的压力将是不同的，但在组内相同。在训练期间和训练后，使用不同的中枢和外周心血管功能测量方法，我将确定每组适应的机制。我的实验室配备了独特的设备，可以使用非侵入性或微创方法执行这项研究计划。 新奇和预期意义目前的方法不足以规定参与者的适当运动压力。这是一个关键的限制，质疑目前的方法来评估控制适应耐力训练的机制的有效性。应用一种新的运动模型，精确控制运动的压力，我的研究计划将：1）证明耐力训练的心血管适应性是由干预的压力决定的; 2）挑战运动“无反应者”的概念。这将为科学家和从业人员提供更有效地开展工作所需的准确信息做出重要贡献。