CEREBRAL IMPACT OF CHILDHOOD SLEEP APNEA

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。阻塞性睡眠呼吸暂停是一种普遍存在的公共卫生问题，可引起神经心理障碍。在成人中的多项研究已经记录了睡眠呼吸暂停与记忆、注意力和额叶系统执行功能异常的相关性。在儿童中进行的少数研究已经证明了呼吸暂停对智商、注意力、行为、记忆和学习的影响。睡眠呼吸暂停的严重程度以及导致儿童神经心理障碍的多导睡眠图参数异常尚不清楚。患有严重阻塞性睡眠呼吸暂停的成年人可能会有永久性的认知障碍，特别是涉及记忆。事实上，有证据表明，在患有中重度睡眠呼吸暂停的成年人中，通过磁共振波谱成像（MRSI）测量脑损伤。睡眠呼吸暂停对大脑的影响尚未在儿童中进行研究。目前尚不清楚睡眠呼吸暂停患者的神经心理功能障碍是否与脑损伤相关。有必要确定儿童阻塞性睡眠呼吸暂停的神经心理学和中枢神经系统的结果。这项初步研究的目的是确定睡眠呼吸暂停是否与脑损伤有关。我们未来的资助目标是确定轻度睡眠呼吸暂停对大脑的影响，呼吸暂停对大脑的影响是否随年龄而变化，以及呼吸暂停对大脑的影响是否可逆。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Obstructive sleep apnea, a prevalent public health problem, can cause neuropsychological disturbances. Multiple studies in adults have documented the association of sleep apnea with abnormalities of memory, attention, and executive functions of the frontal system. Small numbers of studies in children have demonstrated effects of apnea on IQ, attention, behavior, memory, and learning. The level of severity of sleep apnea, and the polysomnographic parameter abnormalities that cause neuropsychological disturbances in children is unknown. Adults with severe obstructive sleep apnea may have permanent cognitive impairment, especially involving memory. In fact, there is evidence of cerebral impairment as measured by magnetic resonance spectroscopy imaging (MRSI) in adults with moderate-severe sleep apnea. The impact of sleep apnea on the brain has not been investigated in children. It is unknown if neuropsychological dysfunction correlates with cerebral damage in sleep apnea patients. There is a need to define the neuropsychological and central nervous system outcomes of obstructive sleep apnea in children. The purpose of this pilot study is to identify whether sleep apnea is associated with cerebral impairment. Our goals with future funding are to determine the cerebral impact of mild sleep apnea, whether cerebral impact of apnea changes with age, and whether the cerebral impact of apnea is reversible.