CEREBRAL IMPACT OF CHILDHOOD SLEEP APNEA

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 对成人和儿童的研究表明，阻塞性睡眠呼吸暂停是一种普遍存在的公共健康问题，可导致神经心理障碍。对成年人的多项研究已经证明了睡眠呼吸暂停与额叶记忆、注意力和执行功能异常之间的联系。少量的儿童研究已经证明了呼吸暂停对智商、注意力、行为、记忆和学习的影响。引起儿童神经心理障碍的睡眠呼吸暂停和多导睡眠图参数异常的严重程度尚不清楚。患有严重阻塞性睡眠呼吸暂停的成年人可能有永久性的认知障碍，特别是记忆障碍。事实上，有证据表明，在患有中重度睡眠呼吸暂停的成年人中，磁共振波谱成像测量到了大脑代谢障碍。永久性脑损伤是否与儿童睡眠呼吸暂停有关尚不清楚。目前尚不清楚睡眠呼吸暂停患者的神经心理障碍是否与脑损伤相关。有必要确定儿童阻塞性睡眠呼吸暂停的神经心理和中枢神经系统结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Studies in both adults and children demonstrate that obstructive sleep apnea, a prevalent public health problem, can cause neuropsychological disturbances. Multiple studies in adults have documented the association of sleep apnea with abnormalities of memory, attention, and executive functions of the frontal lobe. Small numbers of studies in children have demonstrated effects of apnea on IQ, attention, behavior, memory, and learning. The level of severity of sleep apnea, and the polysomnographic parameter abnormalities that cause neuropsychological disturbances in children is unknown. Adults with severe obstructive sleep apnea may have permanent cognitive impairments, especially involving memory. In fact, there is evidence of cerebral metabolic impairment as measured by magnetic resonance spectroscopy imaging in adults with moderate-severe sleep apnea. Whether permanent cerebral impairment is associated with childhood sleep apnea is unknown. It is unknown if neuropsychological dysfunction correlates with cerebral damage in sleep apnea patients. There is a need to define the neuropsychological and central nervous system outcomes of obstructive sleep apnea in children.