FUNDAMENTALS OF FUNCTIONAL MRI

功能 MRI 的基础知识

• 批准号: 7375066
• 负责人: JAMES F HYDE
• 金额: $ 0.06万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375066
• 关键词: FUNDAMENTALS; FUNCTIONAL; MRI

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The present study will test the hypothesis that dynamic BOLD fMRI contrast has vascular and metabolic components that vary over time and space, and that with sufficient a priori information, measurement of particular aspects of the BOLD signal can provide unique information about the physiological events resulting from task activation. We further hypothesize that because of their mechanistic specificity, "perfusion contrast" fMRI techniques will provide improved physiological spatial accuracy and magnitude correlation corresponding to neuronal activity. To test this hypothesis, the following four specific aims will be addressed: 1) to characterize the influence of resting blood flow (CBF), blood volume (CBV), oxygen uptake and vascular architecture on the activation-induced BOLD signal; 2) to determine the physiological spatial resolution of the fMRI signal corresponding to neural activation; 3) to determine the temporal characteristics of the fMRI signal related to neuronal activity; and 4) to determine the physiological (neuronal) basis of spatially correlated spontaneous fluctuations in flow/BOLD in human and animal brain.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。本研究将检验这样的假设：动态 BOLD fMRI 对比具有随时间和空间变化的血管和代谢成分，并且通过足够的先验信息，对 BOLD 信号特定方面的测量可以提供有关任务激活所产生的生理事件的独特信息。我们进一步假设，由于其机械特异性，“灌注对比”fMRI 技术将提供改进的生理空间精度和与神经元活动相对应的幅度相关性。为了检验这一假设，将解决以下四个具体目标：1）表征静息血流量（CBF）、血容量（CBV）、摄氧量和血管结构对激活诱导的 BOLD 信号的影响； 2)确定神经激活对应的fMRI信号的生理空间分辨率； 3）确定与神经元活动相关的fMRI信号的时间特征； 4) 确定人类和动物大脑中流量/BOLD 空间相关自发波动的生理（神经元）基础。