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Experimental studies on the therapeutic efficacies of zonisamide on Parkinson disease

Experimental studies on the therapeutic efficacies of zonisamide on Parkinson disease
唑尼沙胺治疗帕金森病疗效的实验研究
批准号:
21591118
负责人:
MIWA Hideto
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
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英文摘要
Zonisamide is an anti-epileptic drug, and it can be used for treatment of Parkinson disease(PD). However, the pharmacological mechanisms underlying the anti-parkinsonian effects remain unclear. In the present study, we performed animal experiments using experimental tremor models, and could obtain data suggesting that not only zonisamide but also the other T-type calcium channel blockers have the anti-tremor effect. It is expected that T-type calcium channel would be a new therapeutic target of tremors.
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DOI: 10.1007/s12311-011-0277-y
发表时间: 2011-09-01
期刊: CEREBELLUM
影响因子: 3.5
作者: [Miwa, Hideto, Kondo, Tomoyoshi]
通讯作者: Kondo, Tomoyoshi
シンポジウム: Motor fluctuationの新展開とゾニサイドの位置づけ
研讨会:运动波动的新进展及杀虫剂的定位
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Miwa H, Kubo T, Hama-Kobayashi K, Kajimoto Y, Kondo T, 三輪英人]
通讯作者: 三輪英人
Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats : a potential mechanism underlying its anti-parkin sonian tremor effect
在他克林诱导的大鼠下颌运动条件下,唑尼沙胺对 c-Fos 表达的影响:其抗帕金索尼安震颤作用的潜在机制
DOI: --
发表时间: 2009
期刊: Parkinsonism Relat Disord 15
影响因子: --
作者: [Miwa H, Kubo T, Suzuki A, et al.]
通讯作者: et al.
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [高真守, 梶本賀義, 三輪英人, 近藤智善]
通讯作者: 近藤智善
10
    海外基金