EFFECT OF CITALOPRAM ON WORRY-INDUCED RCBF CHANGES

西酞普兰对忧虑引起的 RBF 变化的影响

• 批准号: 7378898
• 负责人: Rudolf Franz Walter Hoehn-Saric
• 金额: $ 0.03万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7378898
• 关键词: EFFECT; CITALOPRAM; WORRY; INDUCED; RCBF

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The study added 4 patients with GAD to increase the sample and permit better statistical analysis of the data. Ten patients with GAD were scanned, using fMRI, before and after 7 weeks of treatment with citalopram. Imaging consisted in measuring BOLD responses while 1. inducing anxiety by hearing sentences that described a personal worry versus emotionally neutral sentences and 2.a decision making task, by measuring when a indistinctly drawn picture was recognized.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。该研究增加了4例GAD患者，以增加样本量，并允许更好地对数据进行统计分析。10名GAD患者在接受西酞普兰治疗7周前后进行了fMRI扫描。成像包括测量BOLD响应，而1.通过听描述个人担忧的句子与情感中性的句子来诱导焦虑; 2.一项决策任务，通过测量何时识别出模糊的图画。