ROLE OF THE BED NUCLEUS IN NORMAL AND GENERALIZED ANXIETY

床核在正常和普遍焦虑中的作用

• 批准号: 7604705
• 负责人: Rudolf Franz Walter Hoehn-Saric
• 金额: $ 0.07万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604705
• 关键词: Amygdaloid structure; Animals; Anxiety; Beds; Brain; Brain region; Cell Nucleus; Collaborations; Computer Retrieval of Information on Scientific Projects Database; Cues; Fright; Functional disorder; Funding; Future; Generalized Anxiety Disorder; Grant; Human; Imaging Techniques; Individual; Institution; Intervention; Knowledge; Methods; Neurobiology; Research; Research Personnel; Resources; Role; Science; Source; Staging; Structure of terminal stria nuclei of preoptic region; Time; United States National Institutes of Health; Universities; human study; member; neuroimaging; novel; psychologic

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Anxiety manifests itself as a fear, namely a cued anxiety, or in a generalized "free floating" form. Animal and human studies demonstrated the role of the amygdala in the acquisition of cued anxiety. However, recent animal studies suggest that the bed nucleus of the stria terminalis (BNST), rather than the amygdala, is essential in manifestations of uncued anxiety. Therefore, Davis (1) has proposed, that a dysfunction in the BNST may be responsible for generalized anxiety disorder (GAD). The aim of the proposed study is to examine the effects of two anxiety-provoking tasks, one cued and one uncued, on the amygdala and BNST in individuals with GAD and non-anxious controls, using new imaging techniques developed in the Department of Psychological and Brain Sciences at Johns Hopkins University. These novel neuroimaging methods permit, for the first time, analysis of brain activation in extremely small brain regions, such as the BNST. A demonstration that the BNST is, in contrast to the amygdala, more activated by non-cued than cued tasks and more activated in individuals with generalized anxiety would significantly advance our knowledge of the neurobiology of normal and pathological anxiety in humans. Moreover, it would set the stage for future studies to assess the effects of various treatment interventions on BNST activity in pathological anxiety states. Collaboration with members of the Department of Psychological and Brain Sciences at Johns Hopkins University will permit above outlined explorations that may have a significant expansion of our knowledge of the neurobiology of anxiety.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 焦虑表现为一种恐惧，也就是一种暗示焦虑，或者是一种广义的“自由漂浮”形式。动物和人类的研究表明，杏仁核在获得线索焦虑症中的作用。然而，最近的动物研究表明，在无提示焦虑的表现中，终纹床核(BNST)而不是杏仁核是必不可少的。因此，Davis(1)提出，BNST的功能障碍可能是广泛性焦虑症(GAD)的原因。这项拟议的研究的目的是利用约翰·霍普金斯大学心理和脑科学系开发的新成像技术，研究两种引发焦虑的任务，一种线索任务和一种非线索任务，对患有广泛性AD和非焦虑对照组的个体的杏仁核和BNST的影响。这些新的神经成像方法首次允许分析极小大脑区域的大脑激活，例如BNST。证明BNST与杏仁核相反，在非线索任务中比线索任务更活跃，在患有广泛性焦虑的个体中也更活跃，这将极大地促进我们对人类正常和病理性焦虑的神经生物学的了解。此外，它将为未来评估各种治疗干预对病理性焦虑状态下BNST活性的影响的研究奠定基础。与约翰霍普金斯大学心理和脑科学系成员的合作将使上述探索成为可能，这些探索可能会极大地扩展我们对焦虑的神经生物学的知识。