ANTIDEPRESSANT EFFECTS ON REGIONAL CEREBRAL BLOOD FLOW IN OCD

这项研究检测了两种不同的抗抑郁药的效果，一种是抗抑郁药， 5-羟色胺再摄取抑制剂和另一种去甲肾上腺素再摄取抑制剂 抑郁症和强迫症抑制剂。 SPECT扫描 在治疗前和治疗结束时检查大脑的变化， 与药物和临床核心相关的血流。 17名患者完成了研究。 所有17名患者都有 药物治疗前和药物治疗12周后的SPECT扫描， 也做了核磁共振 另外三名患者只接受了一次扫描， 他们在研究完成前退出了研究。 这项研究是 已完成，并对数据进行了初步分析， 1995年12月在圣胡安举行的土著人民协商会议上提出。 研究已经完成，数据已经分析。 的 结果如下：1）对药物有反应的患者也 显示rCBF变化（前额叶血流减少， 比左更右）。 没有改善的患者没有表现出这种 变化2)随后好转的患者内侧rCBF较高 额部和尾状核比扫描时没有改善的人好 在他们接受药物治疗之前。 基于这些发现，我们 向国家精神卫生研究所申请补助金

The study examines the effect of two different antidepressants, one a serotonin reuptake inhibitor and another a norepinephrine reuptake inhibitor on depression and obsessive-compulsive symptoms. SPECT scans taken before and at the end of treatment examined changes in cerebral blood flow related to medication and clinical cores. Seventeen patients have completed the study. All seventeen patients had SPECT scans before medication and after twelve weeks of medication and also had MRI'S. An additional three patients had only one scan because they dropped out of the study before completion. The study is completed and the data have been analyzed with preliminary results presented at the ACNP meeting in San Juan, December 1995. The study has been completed and the data has been analyzed. The findngs are as follows: 1) Patients who responded to medication also showed change of rCBF (reduced blood flow in anterior frontal region, more right than left). Patients who did not improve showed no such change. 2) Patients who subsequently improved had higher rCBF in medial frontal region and caudate than those who did not improve when scanned before they were placed on medication. Based on these findings, we applied for a grant to the NIMH.